node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDN1 | GNRH1 | ENSP00000368683 | ENSP00000276414 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.939 |
EDN1 | KNG1 | ENSP00000368683 | ENSP00000265023 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.981 |
EDN1 | MLN | ENSP00000368683 | ENSP00000388825 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle | 0.911 |
EDN1 | NPS | ENSP00000368683 | ENSP00000381105 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.954 |
EDN1 | PLCB1 | ENSP00000368683 | ENSP00000338185 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | phospholipase C, beta 1 (phosphoinositide-specific) | 0.901 |
EDN1 | PLCB2 | ENSP00000368683 | ENSP00000260402 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.900 |
EDN1 | PLCB3 | ENSP00000368683 | ENSP00000279230 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.915 |
EDN1 | TAC1 | ENSP00000368683 | ENSP00000321106 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | tachykinin, precursor 1 | 0.960 |
EDN1 | TAC3 | ENSP00000368683 | ENSP00000300108 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function | 0.926 |
EDN1 | TACR2 | ENSP00000368683 | ENSP00000362403 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | tachykinin receptor 2; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- substance K > neuromedin-K > substance P | 0.908 |
GNRH1 | EDN1 | ENSP00000276414 | ENSP00000368683 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.939 |
GNRH1 | KNG1 | ENSP00000276414 | ENSP00000265023 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.914 |
GNRH1 | MLN | ENSP00000276414 | ENSP00000388825 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle | 0.915 |
GNRH1 | NPS | ENSP00000276414 | ENSP00000381105 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.956 |
GNRH1 | PLCB1 | ENSP00000276414 | ENSP00000338185 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | phospholipase C, beta 1 (phosphoinositide-specific) | 0.900 |
GNRH1 | PLCB2 | ENSP00000276414 | ENSP00000260402 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.900 |
GNRH1 | PLCB3 | ENSP00000276414 | ENSP00000279230 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.900 |
GNRH1 | TAC1 | ENSP00000276414 | ENSP00000321106 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | tachykinin, precursor 1 | 0.936 |
GNRH1 | TAC3 | ENSP00000276414 | ENSP00000300108 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function | 0.968 |
GNRH1 | TACR2 | ENSP00000276414 | ENSP00000362403 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | tachykinin receptor 2; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- substance K > neuromedin-K > substance P | 0.911 |