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D3 D3 RTL1 RTL1 INS-IGF2 INS-IGF2 DLK1 DLK1 DIO3 DIO3 FAM129B FAM129B GDF15 GDF15 KEAP1 KEAP1 TP53 TP53 HTATSF1 HTATSF1 UBC UBC
"FAM129B" - family with sequence similarity 129, member B in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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FAM129Bfamily with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro (746 aa)    
Predicted Functional Partners:
DLK1
delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation (383 aa)
            score_image   0.960
KEAP1
kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)
        score_image   score_image   0.947
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (393 aa)
            score_image   0.865
UBC
ubiquitin C (685 aa)
        score_image       0.849
GDF15
growth differentiation factor 15 (308 aa)
            score_image   0.836
RTL1
retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) (1358 aa)
            score_image   0.811
INS-IGF2
INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) (200 aa)
            score_image   0.742
D3
type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development (304 aa)
            score_image   0.720
DIO3
deiodinase, iodothyronine, type III (278 aa)
            score_image   0.700
HTATSF1
HIV-1 Tat specific factor 1; Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus (755 aa)
        score_image       0.644
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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