node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D3 | DIO3 | ENSP00000427336 | ENSP00000352273 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | deiodinase, iodothyronine, type III | 0.576 |
D3 | DLK1 | ENSP00000427336 | ENSP00000340292 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | 0.850 |
D3 | FAM129B | ENSP00000427336 | ENSP00000362409 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.720 |
D3 | RTL1 | ENSP00000427336 | ENSP00000435342 | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.840 |
DIO3 | D3 | ENSP00000352273 | ENSP00000427336 | deiodinase, iodothyronine, type III | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.576 |
DIO3 | DLK1 | ENSP00000352273 | ENSP00000340292 | deiodinase, iodothyronine, type III | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | 0.831 |
DIO3 | FAM129B | ENSP00000352273 | ENSP00000362409 | deiodinase, iodothyronine, type III | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.700 |
DIO3 | RTL1 | ENSP00000352273 | ENSP00000435342 | deiodinase, iodothyronine, type III | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.821 |
DLK1 | D3 | ENSP00000340292 | ENSP00000427336 | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.850 |
DLK1 | DIO3 | ENSP00000340292 | ENSP00000352273 | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | deiodinase, iodothyronine, type III | 0.831 |
DLK1 | FAM129B | ENSP00000340292 | ENSP00000362409 | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.960 |
DLK1 | RTL1 | ENSP00000340292 | ENSP00000435342 | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.835 |
FAM129B | D3 | ENSP00000362409 | ENSP00000427336 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development | 0.720 |
FAM129B | DIO3 | ENSP00000362409 | ENSP00000352273 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | deiodinase, iodothyronine, type III | 0.700 |
FAM129B | DLK1 | ENSP00000362409 | ENSP00000340292 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | delta-like 1 homolog (Drosophila); May have a role in neuroendocrine differentiation | 0.960 |
FAM129B | GDF15 | ENSP00000362409 | ENSP00000252809 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | growth differentiation factor 15 | 0.836 |
FAM129B | HTATSF1 | ENSP00000362409 | ENSP00000218364 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | HIV-1 Tat specific factor 1; Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus | 0.644 |
FAM129B | INS-IGF2 | ENSP00000362409 | ENSP00000348986 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | INS-IGF2 readthrough; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.742 |
FAM129B | KEAP1 | ENSP00000362409 | ENSP00000171111 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | 0.947 |
FAM129B | RTL1 | ENSP00000362409 | ENSP00000435342 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | retrotransposon-like 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta (By similarity) | 0.811 |