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TJP1 TJP1 CLEC2A CLEC2A KCNQ3 KCNQ3 RPL34 RPL34 GJB3 GJB3 KCNQ4 KCNQ4 SLC26A4 SLC26A4 CNST CNST TECTA TECTA TMC1 TMC1 PKP1 PKP1
"GJB3" - gap junction protein, beta 3, 31kDa in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
GJB3gap junction protein, beta 3, 31kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (270 aa)    
Predicted Functional Partners:
KCNQ4
potassium voltage-gated channel, KQT-like subfamily, member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors (695 aa)
            score_image   0.811
RPL34
ribosomal protein L34 (117 aa)
            score_image   0.800
SLC26A4
solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide (780 aa)
            score_image   0.633
TJP1
tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (1748 aa)
        score_image       0.576
CNST
consortin, connexin sorting protein; Required for targeting of connexins to the plasma membrane (725 aa)
        score_image       0.567
TECTA
tectorin alpha; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals (2155 aa)
            score_image   0.565
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (872 aa)
            score_image   0.562
CLEC2A
C-type lectin domain family 2, member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity (174 aa)
            score_image   0.561
PKP1
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome); Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis (747 aa)
            score_image   0.501
TMC1
transmembrane channel-like 1; Probable ion channel required for the normal function of cochlear hair cells (By similarity) (760 aa)
            score_image   0.480
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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