node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMPK1 | ITPA | ENSP00000360939 | ENSP00000369456 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 0.916 |
CMPK1 | UCK2 | ENSP00000360939 | ENSP00000356853 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine | 0.946 |
CMPK1 | UCKL1 | ENSP00000360939 | ENSP00000346155 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.924 |
CMPK1 | UMPS | ENSP00000360939 | ENSP00000232607 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | uridine monophosphate synthetase | 0.928 |
CMPK1 | UPRT | ENSP00000360939 | ENSP00000362481 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.952 |
DPYD | PNP | ENSP00000359211 | ENSP00000354532 | dihydropyrimidine dehydrogenase | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) | 0.923 |
DPYD | TYMP | ENSP00000359211 | ENSP00000252029 | dihydropyrimidine dehydrogenase | thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro | 0.990 |
DPYD | UCK2 | ENSP00000359211 | ENSP00000356853 | dihydropyrimidine dehydrogenase | uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine | 0.529 |
DPYD | UCKL1 | ENSP00000359211 | ENSP00000346155 | dihydropyrimidine dehydrogenase | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.635 |
DPYD | UMPS | ENSP00000359211 | ENSP00000232607 | dihydropyrimidine dehydrogenase | uridine monophosphate synthetase | 0.998 |
DPYD | UPP1 | ENSP00000359211 | ENSP00000330032 | dihydropyrimidine dehydrogenase | uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis | 0.967 |
DPYD | UPRT | ENSP00000359211 | ENSP00000362481 | dihydropyrimidine dehydrogenase | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.950 |
ITPA | CMPK1 | ENSP00000369456 | ENSP00000360939 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors | 0.916 |
ITPA | UCK2 | ENSP00000369456 | ENSP00000356853 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine | 0.958 |
ITPA | UCKL1 | ENSP00000369456 | ENSP00000346155 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.928 |
ITPA | UMPS | ENSP00000369456 | ENSP00000232607 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | uridine monophosphate synthetase | 0.923 |
ITPA | UPP1 | ENSP00000369456 | ENSP00000330032 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis | 0.417 |
ITPA | UPRT | ENSP00000369456 | ENSP00000362481 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.920 |
PNP | DPYD | ENSP00000354532 | ENSP00000359211 | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) | dihydropyrimidine dehydrogenase | 0.923 |
PNP | TYMP | ENSP00000354532 | ENSP00000252029 | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) | thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro | 0.591 |