| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAMP | ANGPTL2 | ENSP00000248450 | ENSP00000362524 | angio-associated, migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.541 |
| AKT1 | ANGPTL2 | ENSP00000270202 | ENSP00000362524 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.810 |
| AKT1 | INS | ENSP00000270202 | ENSP00000250971 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.997 |
| AKT1 | TRIB3 | ENSP00000270202 | ENSP00000217233 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | tribbles homolog 3 (Drosophila); Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the ’Thr-308’ phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display k [...] | 0.971 |
| ANGPTL2 | AAMP | ENSP00000362524 | ENSP00000248450 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | angio-associated, migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway | 0.541 |
| ANGPTL2 | AKT1 | ENSP00000362524 | ENSP00000270202 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.810 |
| ANGPTL2 | INS | ENSP00000362524 | ENSP00000250971 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.825 |
| ANGPTL2 | LILRB2 | ENSP00000362524 | ENSP00000375629 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | 0.576 |
| ANGPTL2 | LMOD1 | ENSP00000362524 | ENSP00000356257 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | leiomodin 1 (smooth muscle) | 0.518 |
| ANGPTL2 | NEURL | ENSP00000362524 | ENSP00000358795 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity) | 0.560 |
| ANGPTL2 | NEURL1B | ENSP00000362524 | ENSP00000358815 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands | 0.560 |
| ANGPTL2 | TEK | ENSP00000362524 | ENSP00000369375 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | TEK tyrosine kinase, endothelial; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inh [...] | 0.963 |
| ANGPTL2 | TIE1 | ENSP00000362524 | ENSP00000361554 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis | 0.799 |
| ANGPTL2 | TRIB3 | ENSP00000362524 | ENSP00000217233 | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | tribbles homolog 3 (Drosophila); Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the ’Thr-308’ phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display k [...] | 0.801 |
| INS | AKT1 | ENSP00000250971 | ENSP00000270202 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.997 |
| INS | ANGPTL2 | ENSP00000250971 | ENSP00000362524 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.825 |
| INS | TEK | ENSP00000250971 | ENSP00000369375 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | TEK tyrosine kinase, endothelial; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post- natal hematopoiesis. After birth, activates or inh [...] | 0.896 |
| LILRB2 | ANGPTL2 | ENSP00000375629 | ENSP00000362524 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.576 |
| LMOD1 | ANGPTL2 | ENSP00000356257 | ENSP00000362524 | leiomodin 1 (smooth muscle) | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.518 |
| NEURL | ANGPTL2 | ENSP00000358795 | ENSP00000362524 | neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity) | angiopoietin-like 2; Induces sprouting in endothelial cells through an autocrine and paracrine action | 0.560 |
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