node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFHD2 | ZBTB34 | ENSP00000365147 | ENSP00000362551 | EF-hand domain family, member D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity) | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.542 |
FAM129B | GARNL3 | ENSP00000362409 | ENSP00000362485 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | GTPase activating Rap/RanGAP domain-like 3 | 0.618 |
FAM129B | LRSAM1 | ENSP00000362409 | ENSP00000300417 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos | 0.491 |
FAM129B | ZBTB34 | ENSP00000362409 | ENSP00000362551 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.616 |
FBXL19 | ZBTB34 | ENSP00000369666 | ENSP00000362551 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.501 |
GARNL3 | FAM129B | ENSP00000362485 | ENSP00000362409 | GTPase activating Rap/RanGAP domain-like 3 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.618 |
GARNL3 | LRSAM1 | ENSP00000362485 | ENSP00000300417 | GTPase activating Rap/RanGAP domain-like 3 | leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos | 0.609 |
GARNL3 | ZBTB34 | ENSP00000362485 | ENSP00000362551 | GTPase activating Rap/RanGAP domain-like 3 | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.727 |
KDM2A | ZBTB34 | ENSP00000432786 | ENSP00000362551 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.501 |
KDM2B | ZBTB34 | ENSP00000366271 | ENSP00000362551 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.501 |
LGALS4 | ZBTB34 | ENSP00000302100 | ENSP00000362551 | lectin, galactoside-binding, soluble, 4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.665 |
LRSAM1 | FAM129B | ENSP00000300417 | ENSP00000362409 | leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.491 |
LRSAM1 | GARNL3 | ENSP00000300417 | ENSP00000362485 | leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos | GTPase activating Rap/RanGAP domain-like 3 | 0.609 |
LRSAM1 | ZBTB34 | ENSP00000300417 | ENSP00000362551 | leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.613 |
LZTR1 | ZBTB34 | ENSP00000215739 | ENSP00000362551 | leucine-zipper-like transcription regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.486 |
XRN1 | ZBTB34 | ENSP00000264951 | ENSP00000362551 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger and BTB domain containing 34; May be a transcriptional repressor | 0.543 |
ZBTB34 | EFHD2 | ENSP00000362551 | ENSP00000365147 | zinc finger and BTB domain containing 34; May be a transcriptional repressor | EF-hand domain family, member D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity) | 0.542 |
ZBTB34 | FAM129B | ENSP00000362551 | ENSP00000362409 | zinc finger and BTB domain containing 34; May be a transcriptional repressor | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.616 |
ZBTB34 | FBXL19 | ENSP00000362551 | ENSP00000369666 | zinc finger and BTB domain containing 34; May be a transcriptional repressor | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZBTB34 | GARNL3 | ENSP00000362551 | ENSP00000362485 | zinc finger and BTB domain containing 34; May be a transcriptional repressor | GTPase activating Rap/RanGAP domain-like 3 | 0.727 |