node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDP1 | ZBTB43 | ENSP00000351575 | ENSP00000362556 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.927 |
EIF4A1 | ZBTB43 | ENSP00000293831 | ENSP00000362556 | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.644 |
FAM129B | GARNL3 | ENSP00000362409 | ENSP00000362485 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | GTPase activating Rap/RanGAP domain-like 3 | 0.618 |
FAM129B | ZBTB43 | ENSP00000362409 | ENSP00000362556 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.612 |
GARNL3 | FAM129B | ENSP00000362485 | ENSP00000362409 | GTPase activating Rap/RanGAP domain-like 3 | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.618 |
GARNL3 | ZBTB43 | ENSP00000362485 | ENSP00000362556 | GTPase activating Rap/RanGAP domain-like 3 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.688 |
LAMTOR3 | MSLN | ENSP00000424183 | ENSP00000372313 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | mesothelin | 0.897 |
LAMTOR3 | ZBTB43 | ENSP00000424183 | ENSP00000362556 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.644 |
LNX1 | ZBTB43 | ENSP00000263925 | ENSP00000362556 | ligand of numb-protein X 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity) | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.680 |
MARCKSL1 | ZBTB43 | ENSP00000362638 | ENSP00000362556 | MARCKS-like 1; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.644 |
MPDZ | ZBTB43 | ENSP00000370410 | ENSP00000362556 | multiple PDZ domain protein | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.654 |
MSLN | LAMTOR3 | ENSP00000372313 | ENSP00000424183 | mesothelin | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.897 |
MSLN | ZBTB43 | ENSP00000372313 | ENSP00000362556 | mesothelin | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.934 |
TTC7B | ZBTB43 | ENSP00000336127 | ENSP00000362556 | tetratricopeptide repeat domain 7B | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | 0.599 |
ZBTB43 | BDP1 | ENSP00000362556 | ENSP00000351575 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.927 |
ZBTB43 | EIF4A1 | ENSP00000362556 | ENSP00000293831 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | eukaryotic translation initiation factor 4A1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon | 0.644 |
ZBTB43 | FAM129B | ENSP00000362556 | ENSP00000362409 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | family with sequence similarity 129, member B; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro | 0.612 |
ZBTB43 | GARNL3 | ENSP00000362556 | ENSP00000362485 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | GTPase activating Rap/RanGAP domain-like 3 | 0.688 |
ZBTB43 | LAMTOR3 | ENSP00000362556 | ENSP00000424183 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.644 |
ZBTB43 | LNX1 | ENSP00000362556 | ENSP00000263925 | zinc finger and BTB domain containing 43; May be involved in transcriptional regulation | ligand of numb-protein X 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity) | 0.680 |