TSSK3 protein (Homo sapiens) - STRING network view

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TSSK3

testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function (268 aa)

Predicted Functional Partners:

PHLPP2

0.788

PHLPP1

0.788

LRGUK

0.688

PPTC7

0.661

PPM1L

0.659

PP2D1

0.659

PPM1E

0.659

PPM1D

0.659

PPM1K

0.659

PPM1F

0.659

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LRGUK	PHLPP1	ENSP00000285928	ENSP00000262719	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.665
LRGUK	PHLPP2	ENSP00000285928	ENSP00000348611	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.665
LRGUK	PP2D1	ENSP00000285928	ENSP00000373702	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase 2C-like domain containing 1	0.621
LRGUK	PPM1D	ENSP00000285928	ENSP00000306682	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins	0.621
LRGUK	PPM1E	ENSP00000285928	ENSP00000312411	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42	0.621
LRGUK	PPM1F	ENSP00000285928	ENSP00000263212	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis	0.621
LRGUK	PPM1K	ENSP00000285928	ENSP00000295908	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1K	0.621
LRGUK	PPM1L	ENSP00000285928	ENSP00000417659	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6	0.621
LRGUK	PPTC7	ENSP00000285928	ENSP00000346255	leucine-rich repeats and guanylate kinase domain containing	PTC7 protein phosphatase homolog (S. cerevisiae)	0.621
LRGUK	TSSK3	ENSP00000285928	ENSP00000362634	leucine-rich repeats and guanylate kinase domain containing	testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.688
PHLPP1	LRGUK	ENSP00000262719	ENSP00000285928	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	leucine-rich repeats and guanylate kinase domain containing	0.665
PHLPP1	PHLPP2	ENSP00000262719	ENSP00000348611	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.999
PHLPP1	TSSK3	ENSP00000262719	ENSP00000362634	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.788
PHLPP2	LRGUK	ENSP00000348611	ENSP00000285928	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	leucine-rich repeats and guanylate kinase domain containing	0.665
PHLPP2	PHLPP1	ENSP00000348611	ENSP00000262719	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.999
PHLPP2	TSSK3	ENSP00000348611	ENSP00000362634	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.788
PP2D1	LRGUK	ENSP00000373702	ENSP00000285928	protein phosphatase 2C-like domain containing 1	leucine-rich repeats and guanylate kinase domain containing	0.621
PP2D1	PPTC7	ENSP00000373702	ENSP00000346255	protein phosphatase 2C-like domain containing 1	PTC7 protein phosphatase homolog (S. cerevisiae)	0.516
PP2D1	TSSK3	ENSP00000373702	ENSP00000362634	protein phosphatase 2C-like domain containing 1	testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function	0.659
PPM1D	LRGUK	ENSP00000306682	ENSP00000285928	protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins	leucine-rich repeats and guanylate kinase domain containing	0.621

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