GOLGA1 protein (Homo sapiens) - STRING network view

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GOLGA1

golgin A1; Probably involved in maintaining Golgi structure (767 aa)

Predicted Functional Partners:

TDP1

0.855

SVIP

0.839

RAB6A

0.760

MAP2K1

0.726

MAP2K2

0.726

GCC2

0.725

GOLGA4

0.725

GRIP1

0.695

MAP2K5

0.666

GCC1

0.646

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GCC1	GOLGA1	ENSP00000318821	ENSP00000362656	GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure	golgin A1; Probably involved in maintaining Golgi structure	0.646
GCC1	GOLGA4	ENSP00000318821	ENSP00000349305	GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	0.794
GCC1	GRIP1	ENSP00000318821	ENSP00000381098	GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure	glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons	0.761
GCC2	GOLGA1	ENSP00000307939	ENSP00000362656	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	golgin A1; Probably involved in maintaining Golgi structure	0.725
GCC2	GOLGA4	ENSP00000307939	ENSP00000349305	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	0.776
GCC2	GRIP1	ENSP00000307939	ENSP00000381098	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons	0.861
GCC2	RAB6A	ENSP00000307939	ENSP00000311449	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	0.995
GOLGA1	GCC1	ENSP00000362656	ENSP00000318821	golgin A1; Probably involved in maintaining Golgi structure	GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure	0.646
GOLGA1	GCC2	ENSP00000362656	ENSP00000307939	golgin A1; Probably involved in maintaining Golgi structure	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	0.725
GOLGA1	GOLGA4	ENSP00000362656	ENSP00000349305	golgin A1; Probably involved in maintaining Golgi structure	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	0.725
GOLGA1	GRIP1	ENSP00000362656	ENSP00000381098	golgin A1; Probably involved in maintaining Golgi structure	glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons	0.695
GOLGA1	MAP2K1	ENSP00000362656	ENSP00000302486	golgin A1; Probably involved in maintaining Golgi structure	mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-T [...]	0.726
GOLGA1	MAP2K2	ENSP00000362656	ENSP00000262948	golgin A1; Probably involved in maintaining Golgi structure	mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)	0.726
GOLGA1	MAP2K5	ENSP00000362656	ENSP00000178640	golgin A1; Probably involved in maintaining Golgi structure	mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis	0.666
GOLGA1	RAB6A	ENSP00000362656	ENSP00000311449	golgin A1; Probably involved in maintaining Golgi structure	RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity	0.760
GOLGA1	SVIP	ENSP00000362656	ENSP00000346130	golgin A1; Probably involved in maintaining Golgi structure	small VCP/p97-interacting protein	0.839
GOLGA1	TDP1	ENSP00000362656	ENSP00000337353	golgin A1; Probably involved in maintaining Golgi structure	tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3’-phosphodiester bond, giving rise to DNA with a free 3’ phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3’-phosphoglycolates on protruding 3’ ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3’exonuclease activity and can remove a single nucleoside from the [...]	0.855
GOLGA4	GCC1	ENSP00000349305	ENSP00000318821	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	GRIP and coiled-coil domain containing 1; Probably involved in maintaining Golgi structure	0.794
GOLGA4	GCC2	ENSP00000349305	ENSP00000307939	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2	0.776
GOLGA4	GOLGA1	ENSP00000349305	ENSP00000362656	golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1	golgin A1; Probably involved in maintaining Golgi structure	0.725

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