DENND1A protein (Homo sapiens) - STRING network view

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DENND1A

DENN/MADD domain containing 1A (1009 aa)

Predicted Functional Partners:

RAB35

0.855

MADD

0.823

CLTC

0.768

NEK6

0.689

NEK7

0.687

CRB2

0.669

THADA

0.626

YOD1

0.622

LHX2

0.606

PEX2

0.566

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLTC	DENND1A	ENSP00000269122	ENSP00000362727	clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network	DENN/MADD domain containing 1A	0.768
CLTC	MADD	ENSP00000269122	ENSP00000310933	clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network	MAP-kinase activating death domain	0.687
CLTC	RAB35	ENSP00000269122	ENSP00000229340	clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network	RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge	0.561
CRB2	DENND1A	ENSP00000362734	ENSP00000362727	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	DENN/MADD domain containing 1A	0.669
CRB2	LHX2	ENSP00000362734	ENSP00000362717	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)	0.775
CRB2	NEK6	ENSP00000362734	ENSP00000362702	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence	0.687
CRB2	NEK7	ENSP00000362734	ENSP00000356355	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1	0.685
DENND1A	CLTC	ENSP00000362727	ENSP00000269122	DENN/MADD domain containing 1A	clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network	0.768
DENND1A	CRB2	ENSP00000362727	ENSP00000362734	DENN/MADD domain containing 1A	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	0.669
DENND1A	LHX2	ENSP00000362727	ENSP00000362717	DENN/MADD domain containing 1A	LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)	0.606
DENND1A	MADD	ENSP00000362727	ENSP00000310933	DENN/MADD domain containing 1A	MAP-kinase activating death domain	0.823
DENND1A	NEK6	ENSP00000362727	ENSP00000362702	DENN/MADD domain containing 1A	NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence	0.689
DENND1A	NEK7	ENSP00000362727	ENSP00000356355	DENN/MADD domain containing 1A	NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1	0.687
DENND1A	PEX2	ENSP00000362727	ENSP00000349543	DENN/MADD domain containing 1A	peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes	0.566
DENND1A	RAB35	ENSP00000362727	ENSP00000229340	DENN/MADD domain containing 1A	RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge	0.855
DENND1A	THADA	ENSP00000362727	ENSP00000385995	DENN/MADD domain containing 1A	thyroid adenoma associated	0.626
DENND1A	YOD1	ENSP00000362727	ENSP00000326813	DENN/MADD domain containing 1A	YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae); Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked [...]	0.622
LHX2	CRB2	ENSP00000362717	ENSP00000362734	LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	0.775
LHX2	DENND1A	ENSP00000362717	ENSP00000362727	LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)	DENN/MADD domain containing 1A	0.606
LHX2	NEK6	ENSP00000362717	ENSP00000362702	LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity)	NIMA-related kinase 6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence	0.610

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