node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATOH7 | GDF11 | ENSP00000362777 | ENSP00000257868 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | 0.972 |
ATOH7 | NEUROG2 | ENSP00000362777 | ENSP00000317333 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.937 |
ATOH7 | NOTCH1 | ENSP00000362777 | ENSP00000277541 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.696 |
ATOH7 | PAX6 | ENSP00000362777 | ENSP00000368401 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.923 |
ATOH7 | POU4F2 | ENSP00000362777 | ENSP00000281321 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.973 |
ATOH7 | SHH | ENSP00000362777 | ENSP00000297261 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.810 |
ATOH7 | TCF12 | ENSP00000362777 | ENSP00000331057 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | 0.853 |
ATOH7 | TCF3 | ENSP00000362777 | ENSP00000262965 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.857 |
ATOH7 | TCF4 | ENSP00000362777 | ENSP00000346440 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | transcription factor 4 | 0.852 |
ATOH7 | VSX2 | ENSP00000362777 | ENSP00000261980 | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.722 |
GDF11 | ATOH7 | ENSP00000257868 | ENSP00000362777 | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | 0.972 |
GDF11 | PAX6 | ENSP00000257868 | ENSP00000368401 | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.881 |
GDF11 | SHH | ENSP00000257868 | ENSP00000297261 | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.593 |
NEUROG2 | ATOH7 | ENSP00000317333 | ENSP00000362777 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | 0.937 |
NEUROG2 | NOTCH1 | ENSP00000317333 | ENSP00000277541 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.912 |
NEUROG2 | PAX6 | ENSP00000317333 | ENSP00000368401 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.953 |
NEUROG2 | POU4F2 | ENSP00000317333 | ENSP00000281321 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.507 |
NEUROG2 | SHH | ENSP00000317333 | ENSP00000297261 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.702 |
NEUROG2 | VSX2 | ENSP00000317333 | ENSP00000261980 | neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.570 |
NOTCH1 | ATOH7 | ENSP00000277541 | ENSP00000362777 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | atonal homolog 7 (Drosophila); Transcription factor involved in the differentiation of retinal ganglion cells (By similarity) | 0.696 |