ADO protein (Homo sapiens) - STRING network view

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ADO

2-aminoethanethiol (cysteamine) dioxygenase (270 aa)

Predicted Functional Partners:

CSAD

0.913

GAD2

0.900

GAD1

0.900

CDON

0.785

RPIA

0.655

ADK

0.648

C3

0.610

TRIM33

0.583

ADORA2B

0.581

ADORA1

0.525

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	ADO	ENSP00000286621	ENSP00000362888	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	2-aminoethanethiol (cysteamine) dioxygenase	0.648
ADK	ADORA1	ENSP00000286621	ENSP00000308549	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	0.699
ADK	ADORA2B	ENSP00000286621	ENSP00000304501	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	adenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.414
ADK	RPIA	ENSP00000286621	ENSP00000283646	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	ribose 5-phosphate isomerase A	0.463
ADK	TRIM33	ENSP00000286621	ENSP00000351250	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	tripartite motif containing 33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed-16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as a [...]	0.720
ADO	ADK	ENSP00000362888	ENSP00000286621	2-aminoethanethiol (cysteamine) dioxygenase	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	0.648
ADO	ADORA1	ENSP00000362888	ENSP00000308549	2-aminoethanethiol (cysteamine) dioxygenase	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	0.525
ADO	ADORA2B	ENSP00000362888	ENSP00000304501	2-aminoethanethiol (cysteamine) dioxygenase	adenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.581
ADO	C3	ENSP00000362888	ENSP00000245907	2-aminoethanethiol (cysteamine) dioxygenase	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.610
ADO	CDON	ENSP00000362888	ENSP00000263577	2-aminoethanethiol (cysteamine) dioxygenase	Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity)	0.785
ADO	CSAD	ENSP00000362888	ENSP00000267085	2-aminoethanethiol (cysteamine) dioxygenase	cysteine sulfinic acid decarboxylase	0.913
ADO	GAD1	ENSP00000362888	ENSP00000350928	2-aminoethanethiol (cysteamine) dioxygenase	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.900
ADO	GAD2	ENSP00000362888	ENSP00000259271	2-aminoethanethiol (cysteamine) dioxygenase	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.900
ADO	RPIA	ENSP00000362888	ENSP00000283646	2-aminoethanethiol (cysteamine) dioxygenase	ribose 5-phosphate isomerase A	0.655
ADO	TRIM33	ENSP00000362888	ENSP00000351250	2-aminoethanethiol (cysteamine) dioxygenase	tripartite motif containing 33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed-16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as a [...]	0.583
ADORA1	ADK	ENSP00000308549	ENSP00000286621	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides	0.699
ADORA1	ADO	ENSP00000308549	ENSP00000362888	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	2-aminoethanethiol (cysteamine) dioxygenase	0.525
ADORA1	C3	ENSP00000308549	ENSP00000245907	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.900
ADORA1	RPIA	ENSP00000308549	ENSP00000283646	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	ribose 5-phosphate isomerase A	0.935
ADORA1	TRIM33	ENSP00000308549	ENSP00000351250	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	tripartite motif containing 33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed-16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as a [...]	0.720

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