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STRINGSTRING
CERKL CERKL CERS4 CERS4 SMPD2 SMPD2 SMPDL3B SMPDL3B ABCA13 ABCA13 ABCA12 ABCA12
"SMPDL3B" - sphingomyelin phosphodiesterase, acid-like 3B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SMPDL3Bsphingomyelin phosphodiesterase, acid-like 3B (455 aa)    
Predicted Functional Partners:
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase); Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (423 aa)
            score_image   0.698
CERS4
ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) (394 aa)
            score_image   0.484
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12; Probable transporter involved in lipid homeostasis (2595 aa)
            score_image   0.450
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13 (5058 aa)
            score_image   0.449
CERKL
ceramide kinase-like (558 aa)
            score_image   0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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