| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARNTL | BHLHE40 | ENSP00000374357 | ENSP00000256495 | aryl hydrocarbon receptor nuclear translocator-like | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | 0.989 |
| ARNTL | CLOCK | ENSP00000374357 | ENSP00000308741 | aryl hydrocarbon receptor nuclear translocator-like | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | 0.999 |
| ARNTL | DEC1 | ENSP00000374357 | ENSP00000363128 | aryl hydrocarbon receptor nuclear translocator-like | deleted in esophageal cancer 1; Candidate tumor suppressor | 0.908 |
| ARNTL | HDAC1 | ENSP00000374357 | ENSP00000362649 | aryl hydrocarbon receptor nuclear translocator-like | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.457 |
| ARNTL | HDAC2 | ENSP00000374357 | ENSP00000430432 | aryl hydrocarbon receptor nuclear translocator-like | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.411 |
| BHLHE40 | ARNTL | ENSP00000256495 | ENSP00000374357 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | aryl hydrocarbon receptor nuclear translocator-like | 0.989 |
| BHLHE40 | CLOCK | ENSP00000256495 | ENSP00000308741 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | 0.958 |
| BHLHE40 | DEC1 | ENSP00000256495 | ENSP00000363128 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | deleted in esophageal cancer 1; Candidate tumor suppressor | 0.954 |
| BHLHE40 | HDAC1 | ENSP00000256495 | ENSP00000362649 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.858 |
| BHLHE40 | MDM2 | ENSP00000256495 | ENSP00000417281 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) | 0.639 |
| BHLHE40 | TP53 | ENSP00000256495 | ENSP00000269305 | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.967 |
| CLOCK | ARNTL | ENSP00000308741 | ENSP00000374357 | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | aryl hydrocarbon receptor nuclear translocator-like | 0.999 |
| CLOCK | BHLHE40 | ENSP00000308741 | ENSP00000256495 | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | 0.958 |
| CLOCK | DEC1 | ENSP00000308741 | ENSP00000363128 | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | deleted in esophageal cancer 1; Candidate tumor suppressor | 0.911 |
| CLOCK | HDAC1 | ENSP00000308741 | ENSP00000362649 | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.400 |
| DEC1 | ARNTL | ENSP00000363128 | ENSP00000374357 | deleted in esophageal cancer 1; Candidate tumor suppressor | aryl hydrocarbon receptor nuclear translocator-like | 0.908 |
| DEC1 | BHLHE40 | ENSP00000363128 | ENSP00000256495 | deleted in esophageal cancer 1; Candidate tumor suppressor | basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway | 0.954 |
| DEC1 | CLOCK | ENSP00000363128 | ENSP00000308741 | deleted in esophageal cancer 1; Candidate tumor suppressor | clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...] | 0.911 |
| DEC1 | HDAC1 | ENSP00000363128 | ENSP00000362649 | deleted in esophageal cancer 1; Candidate tumor suppressor | histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium s [...] | 0.576 |
| DEC1 | HDAC2 | ENSP00000363128 | ENSP00000430432 | deleted in esophageal cancer 1; Candidate tumor suppressor | histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] | 0.576 |
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