node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG7 | ATG9A | ENSP00000346437 | ENSP00000355173 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | autophagy related 9A | 0.873 |
ATG7 | C6orf106 | ENSP00000346437 | ENSP00000363135 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | chromosome 6 open reading frame 106 | 0.438 |
ATG7 | UBC | ENSP00000346437 | ENSP00000344818 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | ubiquitin C | 0.635 |
ATG9A | ATG7 | ENSP00000355173 | ENSP00000346437 | autophagy related 9A | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.873 |
ATG9A | C6orf106 | ENSP00000355173 | ENSP00000363135 | autophagy related 9A | chromosome 6 open reading frame 106 | 0.455 |
ATG9A | UBC | ENSP00000355173 | ENSP00000344818 | autophagy related 9A | ubiquitin C | 0.861 |
C17orf67 | C6orf106 | ENSP00000380960 | ENSP00000363135 | chromosome 17 open reading frame 67 | chromosome 6 open reading frame 106 | 0.470 |
C6orf106 | ATG7 | ENSP00000363135 | ENSP00000346437 | chromosome 6 open reading frame 106 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.438 |
C6orf106 | ATG9A | ENSP00000363135 | ENSP00000355173 | chromosome 6 open reading frame 106 | autophagy related 9A | 0.455 |
C6orf106 | C17orf67 | ENSP00000363135 | ENSP00000380960 | chromosome 6 open reading frame 106 | chromosome 17 open reading frame 67 | 0.470 |
C6orf106 | CLPS | ENSP00000363135 | ENSP00000259938 | chromosome 6 open reading frame 106 | colipase, pancreatic; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase | 0.526 |
C6orf106 | PLPL | ENSP00000363135 | ENSP00000469474 | chromosome 6 open reading frame 106 | uncharacterized protein C14orf162 | 0.505 |
C6orf106 | SLC26A8 | ENSP00000363135 | ENSP00000347778 | chromosome 6 open reading frame 106 | solute carrier family 26, member 8; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility | 0.547 |
C6orf106 | SRPK1 | ENSP00000363135 | ENSP00000362931 | chromosome 6 open reading frame 106 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.534 |
C6orf106 | TTC39B | ENSP00000363135 | ENSP00000422496 | chromosome 6 open reading frame 106 | tetratricopeptide repeat domain 39B | 0.472 |
C6orf106 | UBC | ENSP00000363135 | ENSP00000344818 | chromosome 6 open reading frame 106 | ubiquitin C | 0.929 |
C6orf106 | UBXN2B | ENSP00000363135 | ENSP00000382507 | chromosome 6 open reading frame 106 | UBX domain protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity | 0.508 |
CLPS | C6orf106 | ENSP00000259938 | ENSP00000363135 | colipase, pancreatic; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase | chromosome 6 open reading frame 106 | 0.526 |
PLPL | C6orf106 | ENSP00000469474 | ENSP00000363135 | uncharacterized protein C14orf162 | chromosome 6 open reading frame 106 | 0.505 |
SLC26A8 | C6orf106 | ENSP00000347778 | ENSP00000363135 | solute carrier family 26, member 8; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility | chromosome 6 open reading frame 106 | 0.547 |