| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC12 | NGLY1 | ENSP00000292314 | ENSP00000280700 | coiled-coil domain containing 12 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | 0.648 |
| CCDC12 | ZDHHC18 | ENSP00000292314 | ENSP00000363257 | coiled-coil domain containing 12 | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.711 |
| DDX24 | ZDHHC18 | ENSP00000328690 | ENSP00000363257 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 24; ATP-dependent RNA helicase (Potential) | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.543 |
| ETF1 | GSPT1 | ENSP00000353741 | ENSP00000398131 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.999 |
| ETF1 | GSPT2 | ENSP00000353741 | ENSP00000341247 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.997 |
| ETF1 | ZDHHC18 | ENSP00000353741 | ENSP00000363257 | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.726 |
| FAF2 | GOLGA7 | ENSP00000261942 | ENSP00000350378 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | golgin A7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS | 0.548 |
| FAF2 | GOLGA7B | ENSP00000261942 | ENSP00000359634 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | golgin A7 family, member B; May be involved in protein transport from Golgi to cell surface (By similarity) | 0.601 |
| FAF2 | ZDHHC18 | ENSP00000261942 | ENSP00000363257 | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.561 |
| GOLGA7 | FAF2 | ENSP00000350378 | ENSP00000261942 | golgin A7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | 0.548 |
| GOLGA7 | ZDHHC18 | ENSP00000350378 | ENSP00000363257 | golgin A7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.634 |
| GOLGA7B | FAF2 | ENSP00000359634 | ENSP00000261942 | golgin A7 family, member B; May be involved in protein transport from Golgi to cell surface (By similarity) | Fas associated factor family member 2; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome | 0.601 |
| GOLGA7B | ZDHHC18 | ENSP00000359634 | ENSP00000363257 | golgin A7 family, member B; May be involved in protein transport from Golgi to cell surface (By similarity) | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.561 |
| GSPT1 | ETF1 | ENSP00000398131 | ENSP00000353741 | G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.999 |
| GSPT1 | GSPT2 | ENSP00000398131 | ENSP00000341247 | G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.571 |
| GSPT1 | ZDHHC18 | ENSP00000398131 | ENSP00000363257 | G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.603 |
| GSPT2 | ETF1 | ENSP00000341247 | ENSP00000353741 | G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | eukaryotic translation termination factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.997 |
| GSPT2 | GSPT1 | ENSP00000341247 | ENSP00000398131 | G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | G1 to S phase transition 1; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | 0.571 |
| GSPT2 | ZDHHC18 | ENSP00000341247 | ENSP00000363257 | G1 to S phase transition 2; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons | zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) | 0.603 |
| NGLY1 | CCDC12 | ENSP00000280700 | ENSP00000292314 | N-glycanase 1; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for sub [...] | coiled-coil domain containing 12 | 0.648 |
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