GRM4 protein (Homo sapiens) - STRING network view

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GRM4

glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity (912 aa)

Predicted Functional Partners:

APP

0.964

GNAT3

0.954

HTR1A

0.934

CNR1

0.932

ADORA1

0.928

HRH3

0.927

NPY

0.921

RGS4

0.920

HTR1B

0.920

DRD2

0.920

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA1	APP	ENSP00000308549	ENSP00000284981	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	amyloid beta (A4) precursor protein	0.900
ADORA1	CNR1	ENSP00000308549	ENSP00000358511	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	cannabinoid receptor 1 (brain)	0.912
ADORA1	DRD2	ENSP00000308549	ENSP00000354859	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	0.911
ADORA1	GNAT3	ENSP00000308549	ENSP00000381339	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	guanine nucleotide binding protein, alpha transducing 3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultima [...]	0.905
ADORA1	GRM4	ENSP00000308549	ENSP00000363296	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	0.928
ADORA1	HRH3	ENSP00000308549	ENSP00000342560	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	histamine receptor H3; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization	0.901
ADORA1	HTR1A	ENSP00000308549	ENSP00000316244	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity	0.911
ADORA1	HTR1B	ENSP00000308549	ENSP00000358963	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity	0.908
ADORA1	NPY	ENSP00000308549	ENSP00000242152	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.933
ADORA1	RGS4	ENSP00000308549	ENSP00000397181	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein	0.921
APP	ADORA1	ENSP00000284981	ENSP00000308549	amyloid beta (A4) precursor protein	adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase	0.900
APP	CNR1	ENSP00000284981	ENSP00000358511	amyloid beta (A4) precursor protein	cannabinoid receptor 1 (brain)	0.911
APP	DRD2	ENSP00000284981	ENSP00000354859	amyloid beta (A4) precursor protein	dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity)	0.904
APP	GNAT3	ENSP00000284981	ENSP00000381339	amyloid beta (A4) precursor protein	guanine nucleotide binding protein, alpha transducing 3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultima [...]	0.900
APP	GRM4	ENSP00000284981	ENSP00000363296	amyloid beta (A4) precursor protein	glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity	0.964
APP	HRH3	ENSP00000284981	ENSP00000342560	amyloid beta (A4) precursor protein	histamine receptor H3; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization	0.900
APP	HTR1A	ENSP00000284981	ENSP00000316244	amyloid beta (A4) precursor protein	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity	0.909
APP	HTR1B	ENSP00000284981	ENSP00000358963	amyloid beta (A4) precursor protein	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity	0.900
APP	NPY	ENSP00000284981	ENSP00000242152	amyloid beta (A4) precursor protein	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.917
APP	RGS4	ENSP00000284981	ENSP00000397181	amyloid beta (A4) precursor protein	regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein	0.900

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