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PKP4 PKP4 ARVCF ARVCF PICK1 PICK1 CTNND1 CTNND1 FRMPD2 FRMPD2 CASK CASK SPIRE2 SPIRE2 NOD2 NOD2 FRMPD3 FRMPD3 FLII FLII GDF10 GDF10
"FRMPD2" - FERM and PDZ domain containing 2 in Homo sapiens
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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homology edge
protein homology
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[Homology]
Score
FRMPD2FERM and PDZ domain containing 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (1309 aa)    
Predicted Functional Partners:
NOD2
nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS) (1040 aa)
             score_image   0.854
PKP4
plakophilin 4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (1192 aa)
             score_image   0.769
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome; Involved in protein-protein interactions at adherens junctions (962 aa)
             score_image   0.762
SPIRE2
spire homolog 2 (Drosophila); Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (714 aa)
             score_image   0.644
CTNND1
catenin (cadherin-associated protein), delta 1 (968 aa)
             score_image   0.631
FRMPD3
FERM and PDZ domain containing 3 (1810 aa)
             score_image   0.564
GDF10
growth differentiation factor 10 (478 aa)
             score_image   0.497
PICK1
protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel (415 aa)
             score_image   0.489
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
             score_image   0.489
FLII
flightless I homolog (Drosophila); May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (1269 aa)
         score_image   score_image   0.476
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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