node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | AURKB | ENSP00000216911 | ENSP00000463999 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | aurora kinase B | 0.928 |
AURKA | UBXN11 | ENSP00000216911 | ENSP00000363338 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | UBX domain protein 11 | 0.831 |
AURKB | AURKA | ENSP00000463999 | ENSP00000216911 | aurora kinase B | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | 0.928 |
AURKB | AURKC | ENSP00000463999 | ENSP00000302898 | aurora kinase B | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | 0.955 |
AURKB | UBXN11 | ENSP00000463999 | ENSP00000363338 | aurora kinase B | UBX domain protein 11 | 0.831 |
AURKC | AURKB | ENSP00000302898 | ENSP00000463999 | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | aurora kinase B | 0.955 |
AURKC | UBXN11 | ENSP00000302898 | ENSP00000363338 | aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] | UBX domain protein 11 | 0.831 |
COL14A1 | ENG | ENSP00000297848 | ENSP00000362299 | collagen, type XIV, alpha 1 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | 0.757 |
COL14A1 | PARL | ENSP00000297848 | ENSP00000325421 | collagen, type XIV, alpha 1 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | 0.824 |
COL14A1 | UBXN11 | ENSP00000297848 | ENSP00000363338 | collagen, type XIV, alpha 1 | UBX domain protein 11 | 0.772 |
ENG | COL14A1 | ENSP00000362299 | ENSP00000297848 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | collagen, type XIV, alpha 1 | 0.757 |
ENG | PARL | ENSP00000362299 | ENSP00000325421 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | 0.822 |
ENG | UBXN11 | ENSP00000362299 | ENSP00000363338 | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | UBX domain protein 11 | 0.810 |
PARL | COL14A1 | ENSP00000325421 | ENSP00000297848 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | collagen, type XIV, alpha 1 | 0.824 |
PARL | ENG | ENSP00000325421 | ENSP00000362299 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | endoglin; Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors | 0.822 |
PARL | UBXN11 | ENSP00000325421 | ENSP00000363338 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | UBX domain protein 11 | 0.824 |
PLAA | UBXN11 | ENSP00000380460 | ENSP00000363338 | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | UBX domain protein 11 | 0.831 |
PLAA | VCP | ENSP00000380460 | ENSP00000351777 | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.998 |
RND1 | UBXN11 | ENSP00000308461 | ENSP00000363338 | Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments | UBX domain protein 11 | 0.899 |
RND3 | UBXN11 | ENSP00000263895 | ENSP00000363338 | Rho family GTPase 3; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins | UBX domain protein 11 | 0.922 |