| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
| ACACA | SPAG4 | ENSP00000344789 | ENSP00000363391 | acetyl-CoA carboxylase alpha | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.810 |
| ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
| ACACB | SPAG4 | ENSP00000341044 | ENSP00000363391 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.810 |
| ERCC8 | GTSF1 | ENSP00000265038 | ENSP00000304185 | excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] | gametocyte specific factor 1 | 0.574 |
| ERCC8 | SPAG4 | ENSP00000265038 | ENSP00000363391 | excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.572 |
| ERCC8 | SPINK6 | ENSP00000265038 | ENSP00000324870 | excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] | serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8 | 0.581 |
| ERCC8 | TMEM4 | ENSP00000265038 | ENSP00000446743 | excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] | Uncharacterized protein | 0.565 |
| GTSF1 | ERCC8 | ENSP00000304185 | ENSP00000265038 | gametocyte specific factor 1 | excision repair cross-complementing rodent repair deficiency, complementation group 8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coup [...] | 0.574 |
| GTSF1 | SPAG4 | ENSP00000304185 | ENSP00000363391 | gametocyte specific factor 1 | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.600 |
| GTSF1 | SPINK6 | ENSP00000304185 | ENSP00000324870 | gametocyte specific factor 1 | serine peptidase inhibitor, Kazal type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8 | 0.656 |
| GTSF1 | TMEM4 | ENSP00000304185 | ENSP00000446743 | gametocyte specific factor 1 | Uncharacterized protein | 0.531 |
| ODF1 | ODF2 | ENSP00000285402 | ENSP00000361882 | outer dense fiber of sperm tails 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail | outer dense fiber of sperm tails 2 | 0.938 |
| ODF1 | SPAG4 | ENSP00000285402 | ENSP00000363391 | outer dense fiber of sperm tails 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.989 |
| ODF1 | SPAG5 | ENSP00000285402 | ENSP00000323300 | outer dense fiber of sperm tails 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail | sperm associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments | 0.782 |
| ODF2 | ODF1 | ENSP00000361882 | ENSP00000285402 | outer dense fiber of sperm tails 2 | outer dense fiber of sperm tails 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail | 0.938 |
| ODF2 | SPAG4 | ENSP00000361882 | ENSP00000363391 | outer dense fiber of sperm tails 2 | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.661 |
| ODF2 | SPAG5 | ENSP00000361882 | ENSP00000323300 | outer dense fiber of sperm tails 2 | sperm associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments | 0.629 |
| SPAG1 | SPAG4 | ENSP00000251809 | ENSP00000363391 | sperm associated antigen 1; Plays a role in fertilization. Binds GTP and has GTPase activity | sperm associated antigen 4; May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail | 0.657 |
| SPAG1 | SPAG5 | ENSP00000251809 | ENSP00000323300 | sperm associated antigen 1; Plays a role in fertilization. Binds GTP and has GTPase activity | sperm associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments | 0.423 |
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