SNX12 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SNX12

sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity) (162 aa)

Predicted Functional Partners:

UBC

0.894

PPM1G

0.893

BACE1

0.810

KIAA1149

0.801

SNX8

0.779

RTN4

0.740

VPS35

0.729

VPS26B

0.704

VPS29

0.697

VPS26A

0.696

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BACE1	RTN4	ENSP00000318585	ENSP00000337838	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	reticulon 4	0.450
BACE1	SNX12	ENSP00000318585	ENSP00000363392	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	0.810
BACE1	UBC	ENSP00000318585	ENSP00000344818	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	ubiquitin C	0.667
KIAA1149	RTN4	ENSP00000292095	ENSP00000337838	beta-secretase 1 isoform E	reticulon 4	0.468
KIAA1149	SNX12	ENSP00000292095	ENSP00000363392	beta-secretase 1 isoform E	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	0.801
PPM1G	SNX12	ENSP00000264714	ENSP00000363392	protein phosphatase, Mg2+/Mn2+ dependent, 1G	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	0.893
PPM1G	UBC	ENSP00000264714	ENSP00000344818	protein phosphatase, Mg2+/Mn2+ dependent, 1G	ubiquitin C	0.928
RTN4	BACE1	ENSP00000337838	ENSP00000318585	reticulon 4	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	0.450
RTN4	KIAA1149	ENSP00000337838	ENSP00000292095	reticulon 4	beta-secretase 1 isoform E	0.468
RTN4	SNX12	ENSP00000337838	ENSP00000363392	reticulon 4	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	0.740
RTN4	SNX8	ENSP00000337838	ENSP00000222990	reticulon 4	sorting nexin 8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network	0.447
RTN4	UBC	ENSP00000337838	ENSP00000344818	reticulon 4	ubiquitin C	0.902
SNX12	BACE1	ENSP00000363392	ENSP00000318585	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	beta-site APP-cleaving enzyme 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase	0.810
SNX12	KIAA1149	ENSP00000363392	ENSP00000292095	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	beta-secretase 1 isoform E	0.801
SNX12	PPM1G	ENSP00000363392	ENSP00000264714	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	protein phosphatase, Mg2+/Mn2+ dependent, 1G	0.893
SNX12	RTN4	ENSP00000363392	ENSP00000337838	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	reticulon 4	0.740
SNX12	SNX8	ENSP00000363392	ENSP00000222990	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	sorting nexin 8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network	0.779
SNX12	UBC	ENSP00000363392	ENSP00000344818	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	ubiquitin C	0.894
SNX12	VPS26A	ENSP00000363392	ENSP00000263559	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	0.696
SNX12	VPS26B	ENSP00000363392	ENSP00000281187	sorting nexin 12; May be involved in several stages of intracellular trafficking (By similarity)	vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity)	0.704

page 1 of 3

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About