PPYR1 protein (Homo sapiens) - STRING network view

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PPYR1

pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid (375 aa)

Predicted Functional Partners:

PYY

0.858

PPY

0.818

GPRIN2

0.817

NPY

0.756

F7

0.614

SYT15

0.582

ALDH5A1

0.552

ZNF74

0.505

ARMCX1

0.487

KNCN

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH5A1	GPRIN2	ENSP00000314649	ENSP00000363433	aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)	G protein regulated inducer of neurite outgrowth 2	0.686
ALDH5A1	PPYR1	ENSP00000314649	ENSP00000363431	aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.552
ARMCX1	PPYR1	ENSP00000361917	ENSP00000363431	armadillo repeat containing, X-linked 1	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.487
F7	PPYR1	ENSP00000364731	ENSP00000363431	coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.614
GPRIN2	ALDH5A1	ENSP00000363433	ENSP00000314649	G protein regulated inducer of neurite outgrowth 2	aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)	0.686
GPRIN2	KNCN	ENSP00000363433	ENSP00000379607	G protein regulated inducer of neurite outgrowth 2	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	0.567
GPRIN2	PPYR1	ENSP00000363433	ENSP00000363431	G protein regulated inducer of neurite outgrowth 2	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.817
GPRIN2	SYT15	ENSP00000363433	ENSP00000363441	G protein regulated inducer of neurite outgrowth 2	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.720
KNCN	GPRIN2	ENSP00000379607	ENSP00000363433	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	G protein regulated inducer of neurite outgrowth 2	0.567
KNCN	PPYR1	ENSP00000379607	ENSP00000363431	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.459
KNCN	SYT15	ENSP00000379607	ENSP00000363441	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.649
NPY	PPY	ENSP00000242152	ENSP00000225992	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	0.915
NPY	PPYR1	ENSP00000242152	ENSP00000363431	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.756
NPY	PYY	ENSP00000242152	ENSP00000353198	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility	0.905
PPY	NPY	ENSP00000225992	ENSP00000242152	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.915
PPY	PPYR1	ENSP00000225992	ENSP00000363431	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.818
PPY	PYY	ENSP00000225992	ENSP00000353198	pancreatic polypeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions	peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility	0.915
PPYR1	ALDH5A1	ENSP00000363431	ENSP00000314649	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)	0.552
PPYR1	ARMCX1	ENSP00000363431	ENSP00000361917	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	armadillo repeat containing, X-linked 1	0.487
PPYR1	F7	ENSP00000363431	ENSP00000364731	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium	0.614

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