SYT15 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SYT15

synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity) (421 aa)

Predicted Functional Partners:

GPRIN2

0.720

KNCN

0.649

POU1F1

0.605

PPYR1

0.582

DMBX1

0.470

GPLD1

0.459

PIK3C2G

0.420

INPP5A

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMBX1	GPRIN2	ENSP00000353132	ENSP00000363433	diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)	G protein regulated inducer of neurite outgrowth 2	0.578
DMBX1	POU1F1	ENSP00000353132	ENSP00000342931	diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)	POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5’- TAAAT-3’	0.402
DMBX1	SYT15	ENSP00000353132	ENSP00000363441	diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.470
GPLD1	SYT15	ENSP00000230036	ENSP00000363441	glycosylphosphatidylinositol specific phospholipase D1	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.459
GPRIN2	DMBX1	ENSP00000363433	ENSP00000353132	G protein regulated inducer of neurite outgrowth 2	diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)	0.578
GPRIN2	INPP5A	ENSP00000363433	ENSP00000357583	G protein regulated inducer of neurite outgrowth 2	inositol polyphosphate-5-phosphatase, 40kDa; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction	0.622
GPRIN2	KNCN	ENSP00000363433	ENSP00000379607	G protein regulated inducer of neurite outgrowth 2	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	0.567
GPRIN2	PPYR1	ENSP00000363433	ENSP00000363431	G protein regulated inducer of neurite outgrowth 2	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.817
GPRIN2	SYT15	ENSP00000363433	ENSP00000363441	G protein regulated inducer of neurite outgrowth 2	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.720
INPP5A	GPRIN2	ENSP00000357583	ENSP00000363433	inositol polyphosphate-5-phosphatase, 40kDa; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction	G protein regulated inducer of neurite outgrowth 2	0.622
INPP5A	SYT15	ENSP00000357583	ENSP00000363441	inositol polyphosphate-5-phosphatase, 40kDa; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.414
KNCN	GPRIN2	ENSP00000379607	ENSP00000363433	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	G protein regulated inducer of neurite outgrowth 2	0.567
KNCN	PPYR1	ENSP00000379607	ENSP00000363431	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	0.459
KNCN	SYT15	ENSP00000379607	ENSP00000363441	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.649
PIK3C2G	SYT15	ENSP00000266497	ENSP00000363441	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity)	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.420
POU1F1	DMBX1	ENSP00000342931	ENSP00000353132	POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5’- TAAAT-3’	diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity)	0.402
POU1F1	SYT15	ENSP00000342931	ENSP00000363441	POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5’- TAAAT-3’	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.605
PPYR1	GPRIN2	ENSP00000363431	ENSP00000363433	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	G protein regulated inducer of neurite outgrowth 2	0.817
PPYR1	KNCN	ENSP00000363431	ENSP00000379607	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking (By similarity)	0.459
PPYR1	SYT15	ENSP00000363431	ENSP00000363441	pancreatic polypeptide receptor 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid	synaptotagmin XV; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues (By similarity)	0.582

page 1 of 2

Textmining

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About