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NRCAM NRCAM GRIK2 GRIK2 DLG1 DLG1 GRIN2B GRIN2B DLG3 DLG3 GDA GDA GRIN2A GRIN2A DLG4 DLG4 GRIN1 GRIN1 GRIN2C GRIN2C ERBB4 ERBB4
"DLG3" - discs, large homolog 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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Predicted Interactions
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[Homology]
Score
DLG3discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa)    
Predicted Functional Partners:
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) (1484 aa)
        score_image score_image score_image   0.999
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits (1464 aa)
        score_image score_image score_image   0.998
NRCAM
neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) (1304 aa)
        score_image score_image score_image   0.984
ERBB4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest c [...] (1308 aa)
        score_image   score_image   0.978
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine (1233 aa)
        score_image score_image score_image   0.959
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
        score_image score_image score_image score_image 0.956
DLG1
discs, large homolog 1 (Drosophila) (926 aa)
        score_image score_image score_image score_image 0.955
GDA
guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) (471 aa)
        score_image   score_image   0.953
GRIK2
glutamate receptor, ionotropic, kainate 2 (908 aa)
        score_image score_image score_image   0.949
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1 (943 aa)
        score_image score_image score_image   0.944
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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