node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLG1 | DLG3 | ENSP00000345731 | ENSP00000363480 | discs, large homolog 1 (Drosophila) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.955 |
DLG1 | DLG4 | ENSP00000345731 | ENSP00000293813 | discs, large homolog 1 (Drosophila) | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
DLG1 | ERBB4 | ENSP00000345731 | ENSP00000342235 | discs, large homolog 1 (Drosophila) | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest c [...] | 0.899 |
DLG1 | GDA | ENSP00000345731 | ENSP00000238018 | discs, large homolog 1 (Drosophila) | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.895 |
DLG1 | GRIK2 | ENSP00000345731 | ENSP00000397026 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, kainate 2 | 0.983 |
DLG1 | GRIN1 | ENSP00000345731 | ENSP00000360608 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.851 |
DLG1 | GRIN2A | ENSP00000345731 | ENSP00000332549 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.998 |
DLG1 | GRIN2B | ENSP00000345731 | ENSP00000279593 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | 0.978 |
DLG1 | GRIN2C | ENSP00000345731 | ENSP00000293190 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, N-methyl D-aspartate 2C; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.797 |
DLG1 | NRCAM | ENSP00000345731 | ENSP00000368314 | discs, large homolog 1 (Drosophila) | neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) | 0.921 |
DLG3 | DLG1 | ENSP00000363480 | ENSP00000345731 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 1 (Drosophila) | 0.955 |
DLG3 | DLG4 | ENSP00000363480 | ENSP00000293813 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.956 |
DLG3 | ERBB4 | ENSP00000363480 | ENSP00000342235 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest c [...] | 0.978 |
DLG3 | GDA | ENSP00000363480 | ENSP00000238018 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity) | 0.953 |
DLG3 | GRIK2 | ENSP00000363480 | ENSP00000397026 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, kainate 2 | 0.949 |
DLG3 | GRIN1 | ENSP00000363480 | ENSP00000360608 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.944 |
DLG3 | GRIN2A | ENSP00000363480 | ENSP00000332549 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.998 |
DLG3 | GRIN2B | ENSP00000363480 | ENSP00000279593 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | 0.999 |
DLG3 | GRIN2C | ENSP00000363480 | ENSP00000293190 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | glutamate receptor, ionotropic, N-methyl D-aspartate 2C; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.959 |
DLG3 | NRCAM | ENSP00000363480 | ENSP00000368314 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) | 0.984 |