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PGM5 PGM5 ENO4 ENO4 PGM1 PGM1 ENO1 ENO1 ENO3 ENO3 MDH1B MDH1B ENO2 ENO2 ACLY ACLY IDH1 IDH1 IDH2 IDH2 SUCLA2 SUCLA2
"MDH1B" - malate dehydrogenase 1B, NAD in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MDH1Bmalate dehydrogenase 1B, NAD (soluble) (518 aa)    
Predicted Functional Partners:
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
score_image     score_image score_image   score_image   0.972
PGM1
phosphoglucomutase 1 (580 aa)
      score_image     score_image   0.856
PGM5
phosphoglucomutase 5 (567 aa)
      score_image     score_image   0.846
ENO4
enolase family member 4 (628 aa)
score_image     score_image     score_image   0.804
ENO3
enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
score_image     score_image     score_image   0.804
ENO1
enolase 1, (alpha) (434 aa)
score_image     score_image     score_image   0.804
ENO2
enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) (434 aa)
score_image     score_image     score_image   0.804
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (452 aa)
score_image     score_image score_image   score_image   0.795
SUCLA2
succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) (463 aa)
score_image     score_image     score_image   0.775
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble (414 aa)
score_image     score_image score_image   score_image   0.764
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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