FUCA1 protein (Homo sapiens) - STRING network view

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FUCA1

fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins (466 aa)

Predicted Functional Partners:

MARK2

0.999

USP16

0.980

USP21

0.891

PGD

0.751

PGM1

0.749

PGM2

0.688

MANBA

0.679

GLB1

0.676

ALPL

0.665

AK2

0.662

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK2	FUCA1	ENSP00000346921	ENSP00000363603	adenylate kinase 2	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	0.662
AK2	PGD	ENSP00000346921	ENSP00000270776	adenylate kinase 2	phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)	0.526
AK2	PGM1	ENSP00000346921	ENSP00000360124	adenylate kinase 2	phosphoglucomutase 1	0.755
AK2	PGM2	ENSP00000346921	ENSP00000371393	adenylate kinase 2	phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity	0.616
ALPL	FUCA1	ENSP00000363965	ENSP00000363603	alkaline phosphatase, liver/bone/kidney	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	0.665
ALPL	GLB1	ENSP00000363965	ENSP00000306920	alkaline phosphatase, liver/bone/kidney	galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans	0.521
ALPL	PGM1	ENSP00000363965	ENSP00000360124	alkaline phosphatase, liver/bone/kidney	phosphoglucomutase 1	0.454
FUCA1	AK2	ENSP00000363603	ENSP00000346921	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	adenylate kinase 2	0.662
FUCA1	ALPL	ENSP00000363603	ENSP00000363965	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	alkaline phosphatase, liver/bone/kidney	0.665
FUCA1	GLB1	ENSP00000363603	ENSP00000306920	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans	0.676
FUCA1	MANBA	ENSP00000363603	ENSP00000226578	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	mannosidase, beta A, lysosomal; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides	0.679
FUCA1	MARK2	ENSP00000363603	ENSP00000385751	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	MAP/microtubule affinity-regulating kinase 2; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity an [...]	0.999
FUCA1	PGD	ENSP00000363603	ENSP00000270776	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)	0.751
FUCA1	PGM1	ENSP00000363603	ENSP00000360124	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	phosphoglucomutase 1	0.749
FUCA1	PGM2	ENSP00000363603	ENSP00000371393	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity	0.688
FUCA1	USP16	ENSP00000363603	ENSP00000334808	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	ubiquitin specific peptidase 16	0.980
FUCA1	USP21	ENSP00000363603	ENSP00000289865	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at ’Lys-4’, resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates	0.891
GLB1	ALPL	ENSP00000306920	ENSP00000363965	galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans	alkaline phosphatase, liver/bone/kidney	0.521
GLB1	FUCA1	ENSP00000306920	ENSP00000363603	galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans	fucosidase, alpha-L- 1, tissue; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins	0.676
GLB1	MANBA	ENSP00000306920	ENSP00000226578	galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans	mannosidase, beta A, lysosomal; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides	0.645

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