node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4GALT1 | GALE | ENSP00000369055 | ENSP00000363621 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.900 |
B4GALT1 | GALT | ENSP00000369055 | ENSP00000368119 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | galactose-1-phosphate uridylyltransferase | 0.900 |
B4GALT1 | LALBA | ENSP00000369055 | ENSP00000301046 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.955 |
B4GALT2 | GALE | ENSP00000310696 | ENSP00000363621 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.900 |
B4GALT2 | GALT | ENSP00000310696 | ENSP00000368119 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | galactose-1-phosphate uridylyltransferase | 0.900 |
ENSG00000258728 | GALE | ENSP00000451792 | ENSP00000363621 | Uncharacterized protein | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.992 |
ENSG00000258728 | GALK1 | ENSP00000451792 | ENSP00000225614 | Uncharacterized protein | galactokinase 1; Major enzyme for galactose metabolism | 0.973 |
ENSG00000258728 | GALK2 | ENSP00000451792 | ENSP00000453129 | Uncharacterized protein | galactokinase 2; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates | 0.973 |
ENSG00000258728 | GALM | ENSP00000451792 | ENSP00000272252 | Uncharacterized protein | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.749 |
ENSG00000258728 | UGP2 | ENSP00000451792 | ENSP00000338703 | Uncharacterized protein | UDP-glucose pyrophosphorylase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways | 0.695 |
GALE | B4GALT1 | ENSP00000363621 | ENSP00000369055 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.900 |
GALE | B4GALT2 | ENSP00000363621 | ENSP00000310696 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.900 |
GALE | ENSG00000258728 | ENSP00000363621 | ENSP00000451792 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | Uncharacterized protein | 0.992 |
GALE | GALK1 | ENSP00000363621 | ENSP00000225614 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactokinase 1; Major enzyme for galactose metabolism | 0.996 |
GALE | GALK2 | ENSP00000363621 | ENSP00000453129 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactokinase 2; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates | 0.988 |
GALE | GALM | ENSP00000363621 | ENSP00000272252 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.959 |
GALE | GALT | ENSP00000363621 | ENSP00000368119 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactose-1-phosphate uridylyltransferase | 0.999 |
GALE | LALBA | ENSP00000363621 | ENSP00000301046 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins | 0.909 |
GALE | UGDH | ENSP00000363621 | ENSP00000319501 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate | 0.980 |
GALE | UGP2 | ENSP00000363621 | ENSP00000338703 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | UDP-glucose pyrophosphorylase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways | 0.958 |