node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADORA1 | IL8 | ENSP00000308549 | ENSP00000306512 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | interleukin 8 | 0.912 |
ADORA1 | KNG1 | ENSP00000308549 | ENSP00000265023 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.956 |
ADORA1 | NPY2R | ENSP00000308549 | ENSP00000332591 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid | 0.905 |
ADORA1 | OXGR1 | ENSP00000308549 | ENSP00000298440 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.929 |
ADORA1 | P2RY12 | ENSP00000308549 | ENSP00000307259 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | purinergic receptor P2Y, G-protein coupled, 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation | 0.932 |
ADORA1 | P2RY13 | ENSP00000308549 | ENSP00000320376 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.930 |
ADORA1 | P2RY14 | ENSP00000308549 | ENSP00000308361 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP | 0.927 |
ADORA1 | P2RY4 | ENSP00000308549 | ENSP00000363643 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.909 |
ADORA1 | RGS18 | ENSP00000308549 | ENSP00000356430 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha | 0.900 |
ADORA1 | SUCNR1 | ENSP00000308549 | ENSP00000355156 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | succinate receptor 1; Receptor for succinate | 0.906 |
IL8 | ADORA1 | ENSP00000306512 | ENSP00000308549 | interleukin 8 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.912 |
IL8 | KNG1 | ENSP00000306512 | ENSP00000265023 | interleukin 8 | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.951 |
IL8 | NPY2R | ENSP00000306512 | ENSP00000332591 | interleukin 8 | neuropeptide Y receptor Y2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid | 0.922 |
IL8 | OXGR1 | ENSP00000306512 | ENSP00000298440 | interleukin 8 | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
IL8 | P2RY12 | ENSP00000306512 | ENSP00000307259 | interleukin 8 | purinergic receptor P2Y, G-protein coupled, 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation | 0.916 |
IL8 | P2RY13 | ENSP00000306512 | ENSP00000320376 | interleukin 8 | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.904 |
IL8 | P2RY14 | ENSP00000306512 | ENSP00000308361 | interleukin 8 | purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP | 0.917 |
IL8 | P2RY4 | ENSP00000306512 | ENSP00000363643 | interleukin 8 | pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.905 |
IL8 | RGS18 | ENSP00000306512 | ENSP00000356430 | interleukin 8 | regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha | 0.900 |
IL8 | SUCNR1 | ENSP00000306512 | ENSP00000355156 | interleukin 8 | succinate receptor 1; Receptor for succinate | 0.902 |