| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EPB41L4B | KLHL3 | ENSP00000363694 | ENSP00000312397 | erythrocyte membrane protein band 4.1 like 4B | kelch-like 3 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex may act by mediating ubiquitination of SLC12A3/NCC, thereby regulating SLC12A3/NCC subcellular location at the cell membrane | 0.428 |
| EPB41L4B | METTL21C | ENSP00000363694 | ENSP00000267273 | erythrocyte membrane protein band 4.1 like 4B | methyltransferase like 21C; Protein-lysine methyltransferase | 0.452 |
| EPB41L4B | MPP5 | ENSP00000363694 | ENSP00000261681 | erythrocyte membrane protein band 4.1 like 4B | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.421 |
| EPB41L4B | PCCA | ENSP00000363694 | ENSP00000365462 | erythrocyte membrane protein band 4.1 like 4B | propionyl CoA carboxylase, alpha polypeptide | 0.414 |
| EPB41L4B | PIN1 | ENSP00000363694 | ENSP00000247970 | erythrocyte membrane protein band 4.1 like 4B | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | 0.483 |
| EPB41L4B | RPRD1A | ENSP00000363694 | ENSP00000349955 | erythrocyte membrane protein band 4.1 like 4B | regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | 0.476 |
| EPB41L4B | TAAR1 | ENSP00000363694 | ENSP00000275216 | erythrocyte membrane protein band 4.1 like 4B | trace amine associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained s [...] | 0.860 |
| EPB41L4B | TP53 | ENSP00000363694 | ENSP00000269305 | erythrocyte membrane protein band 4.1 like 4B | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.483 |
| KLHL3 | EPB41L4B | ENSP00000312397 | ENSP00000363694 | kelch-like 3 (Drosophila); Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex may act by mediating ubiquitination of SLC12A3/NCC, thereby regulating SLC12A3/NCC subcellular location at the cell membrane | erythrocyte membrane protein band 4.1 like 4B | 0.428 |
| METTL21C | EPB41L4B | ENSP00000267273 | ENSP00000363694 | methyltransferase like 21C; Protein-lysine methyltransferase | erythrocyte membrane protein band 4.1 like 4B | 0.452 |
| MPP5 | EPB41L4B | ENSP00000261681 | ENSP00000363694 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | erythrocyte membrane protein band 4.1 like 4B | 0.421 |
| PCCA | EPB41L4B | ENSP00000365462 | ENSP00000363694 | propionyl CoA carboxylase, alpha polypeptide | erythrocyte membrane protein band 4.1 like 4B | 0.414 |
| PIN1 | EPB41L4B | ENSP00000247970 | ENSP00000363694 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | erythrocyte membrane protein band 4.1 like 4B | 0.483 |
| PIN1 | TP53 | ENSP00000247970 | ENSP00000269305 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.999 |
| RPRD1A | EPB41L4B | ENSP00000349955 | ENSP00000363694 | regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | erythrocyte membrane protein band 4.1 like 4B | 0.476 |
| TAAR1 | EPB41L4B | ENSP00000275216 | ENSP00000363694 | trace amine associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained s [...] | erythrocyte membrane protein band 4.1 like 4B | 0.860 |
| TP53 | EPB41L4B | ENSP00000269305 | ENSP00000363694 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | erythrocyte membrane protein band 4.1 like 4B | 0.483 |
| TP53 | PIN1 | ENSP00000269305 | ENSP00000247970 | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | 0.999 |
Share
