| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA7 | FAM206A | ENSP00000345659 | ENSP00000363753 | carbonic anhydrase VII; Reversible hydration of carbon dioxide | family with sequence similarity 206, member A | 0.614 |
| CAT | FAM206A | ENSP00000241052 | ENSP00000363753 | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | family with sequence similarity 206, member A | 0.513 |
| CAT | PEX26 | ENSP00000241052 | ENSP00000331106 | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.514 |
| CAT | PEX5 | ENSP00000241052 | ENSP00000407401 | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.963 |
| CAT | PEX6 | ENSP00000241052 | ENSP00000303511 | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.441 |
| CDKL5 | FAM206A | ENSP00000369325 | ENSP00000363753 | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | family with sequence similarity 206, member A | 0.594 |
| FAM206A | CA7 | ENSP00000363753 | ENSP00000345659 | family with sequence similarity 206, member A | carbonic anhydrase VII; Reversible hydration of carbon dioxide | 0.614 |
| FAM206A | CAT | ENSP00000363753 | ENSP00000241052 | family with sequence similarity 206, member A | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | 0.513 |
| FAM206A | CDKL5 | ENSP00000363753 | ENSP00000369325 | family with sequence similarity 206, member A | cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2 | 0.594 |
| FAM206A | FRRS1L | ENSP00000363753 | ENSP00000363709 | family with sequence similarity 206, member A | ferric-chelate reductase 1-like | 0.753 |
| FAM206A | PEX26 | ENSP00000363753 | ENSP00000331106 | family with sequence similarity 206, member A | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.749 |
| FAM206A | PEX5 | ENSP00000363753 | ENSP00000407401 | family with sequence similarity 206, member A | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.681 |
| FAM206A | PEX6 | ENSP00000363753 | ENSP00000303511 | family with sequence similarity 206, member A | peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.743 |
| FAM206A | PUS10 | ENSP00000363753 | ENSP00000326003 | family with sequence similarity 206, member A | pseudouridylate synthase 10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death | 0.781 |
| FAM206A | RNF152 | ENSP00000363753 | ENSP00000316628 | family with sequence similarity 206, member A | ring finger protein 152; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed | 0.559 |
| FAM206A | SYNJ2BP | ENSP00000363753 | ENSP00000256366 | family with sequence similarity 206, member A | synaptojanin 2 binding protein | 0.800 |
| FRRS1L | FAM206A | ENSP00000363709 | ENSP00000363753 | ferric-chelate reductase 1-like | family with sequence similarity 206, member A | 0.753 |
| PEX26 | CAT | ENSP00000331106 | ENSP00000241052 | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells | 0.514 |
| PEX26 | FAM206A | ENSP00000331106 | ENSP00000363753 | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | family with sequence similarity 206, member A | 0.749 |
| PEX26 | PEX5 | ENSP00000331106 | ENSP00000407401 | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import | 0.779 |
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