node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH1A | AOX1 | ENSP00000209668 | ENSP00000363832 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde oxidase 1 | 0.950 |
ADH1A | HSD17B6 | ENSP00000209668 | ENSP00000318631 | alcohol dehydrogenase 1A (class I), alpha polypeptide | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.499 |
ADH1A | XDH | ENSP00000209668 | ENSP00000368727 | alcohol dehydrogenase 1A (class I), alpha polypeptide | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.578 |
ADH1B | AOX1 | ENSP00000306606 | ENSP00000363832 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde oxidase 1 | 0.952 |
ADH1B | HSD17B6 | ENSP00000306606 | ENSP00000318631 | alcohol dehydrogenase 1B (class I), beta polypeptide | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.499 |
ADH1B | XDH | ENSP00000306606 | ENSP00000368727 | alcohol dehydrogenase 1B (class I), beta polypeptide | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.551 |
ADH4 | ADH7 | ENSP00000265512 | ENSP00000420269 | alcohol dehydrogenase 4 (class II), pi polypeptide | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.591 |
ADH4 | AOX1 | ENSP00000265512 | ENSP00000363832 | alcohol dehydrogenase 4 (class II), pi polypeptide | aldehyde oxidase 1 | 0.920 |
ADH4 | HSD17B6 | ENSP00000265512 | ENSP00000318631 | alcohol dehydrogenase 4 (class II), pi polypeptide | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.512 |
ADH5 | AOX1 | ENSP00000296412 | ENSP00000363832 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | aldehyde oxidase 1 | 0.947 |
ADH5 | XDH | ENSP00000296412 | ENSP00000368727 | alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.599 |
ADH6 | AOX1 | ENSP00000378359 | ENSP00000363832 | alcohol dehydrogenase 6 (class V) | aldehyde oxidase 1 | 0.948 |
ADH6 | HSD17B6 | ENSP00000378359 | ENSP00000318631 | alcohol dehydrogenase 6 (class V) | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.471 |
ADH6 | XDH | ENSP00000378359 | ENSP00000368727 | alcohol dehydrogenase 6 (class V) | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.645 |
ADH7 | ADH4 | ENSP00000420269 | ENSP00000265512 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.591 |
ADH7 | AOX1 | ENSP00000420269 | ENSP00000363832 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | aldehyde oxidase 1 | 0.950 |
ADH7 | HSD17B6 | ENSP00000420269 | ENSP00000318631 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.504 |
ADH7 | XDH | ENSP00000420269 | ENSP00000368727 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | xanthine dehydrogenase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro) | 0.582 |
AOX1 | ADH1A | ENSP00000363832 | ENSP00000209668 | aldehyde oxidase 1 | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.950 |
AOX1 | ADH1B | ENSP00000363832 | ENSP00000306606 | aldehyde oxidase 1 | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.952 |