node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | COL11A2 | ENSP00000368104 | ENSP00000363840 | bone morphogenetic protein 2; Induces cartilage and bone formation | collagen, type XI, alpha 2 | 0.741 |
BMP2 | COMP | ENSP00000368104 | ENSP00000222271 | bone morphogenetic protein 2; Induces cartilage and bone formation | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.437 |
BMP2 | SOX10 | ENSP00000368104 | ENSP00000354130 | bone morphogenetic protein 2; Induces cartilage and bone formation | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.530 |
BMP2 | SOX5 | ENSP00000368104 | ENSP00000398273 | bone morphogenetic protein 2; Induces cartilage and bone formation | SRY (sex determining region Y)-box 5 | 0.472 |
BMP2 | SOX6 | ENSP00000368104 | ENSP00000324948 | bone morphogenetic protein 2; Induces cartilage and bone formation | SRY (sex determining region Y)-box 6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation | 0.471 |
BMP2 | SOX9 | ENSP00000368104 | ENSP00000245479 | bone morphogenetic protein 2; Induces cartilage and bone formation | SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes | 0.966 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | COL11A2 | ENSP00000245451 | ENSP00000363840 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | collagen, type XI, alpha 2 | 0.698 |
BMP4 | SOX10 | ENSP00000245451 | ENSP00000354130 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.708 |
BMP4 | SOX6 | ENSP00000245451 | ENSP00000324948 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | SRY (sex determining region Y)-box 6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation | 0.451 |
BMP4 | SOX9 | ENSP00000245451 | ENSP00000245479 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes | 0.959 |
COL11A2 | BMP2 | ENSP00000363840 | ENSP00000368104 | collagen, type XI, alpha 2 | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.741 |
COL11A2 | BMP4 | ENSP00000363840 | ENSP00000245451 | collagen, type XI, alpha 2 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.698 |
COL11A2 | COMP | ENSP00000363840 | ENSP00000222271 | collagen, type XI, alpha 2 | cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] | 0.756 |
COL11A2 | LHFPL5 | ENSP00000363840 | ENSP00000353346 | collagen, type XI, alpha 2 | lipoma HMGIC fusion partner-like 5; May function in hair bundle morphogenesis (By similarity) | 0.689 |
COL11A2 | RGL2 | ENSP00000363840 | ENSP00000420211 | collagen, type XI, alpha 2 | ral guanine nucleotide dissociation stimulator-like 2; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity) | 0.677 |
COL11A2 | SOX10 | ENSP00000363840 | ENSP00000354130 | collagen, type XI, alpha 2 | SRY (sex determining region Y)-box 10; Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) | 0.850 |
COL11A2 | SOX5 | ENSP00000363840 | ENSP00000398273 | collagen, type XI, alpha 2 | SRY (sex determining region Y)-box 5 | 0.671 |
COL11A2 | SOX6 | ENSP00000363840 | ENSP00000324948 | collagen, type XI, alpha 2 | SRY (sex determining region Y)-box 6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation | 0.775 |