PPP3R2 protein (Homo sapiens) - STRING network view

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PPP3R2

protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) (173 aa)

Predicted Functional Partners:

CALML6

0.907

PLCG2

0.900

PLCG1

0.900

PPP3CB

0.886

PPP3CC

0.880

PPP3CA

0.850

PLCB3

0.840

CALML5

0.831

CALML3

0.831

PLCB1

0.830

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML3	PLCB1	ENSP00000315299	ENSP00000338185	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	phospholipase C, beta 1 (phosphoinositide-specific)	0.820
CALML3	PLCB3	ENSP00000315299	ENSP00000279230	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.820
CALML3	PLCG1	ENSP00000315299	ENSP00000244007	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration	0.806
CALML3	PLCG2	ENSP00000315299	ENSP00000352336	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	phospholipase C, gamma 2 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling	0.800
CALML3	PPP3CA	ENSP00000315299	ENSP00000378323	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	0.884
CALML3	PPP3CB	ENSP00000315299	ENSP00000378306	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.893
CALML3	PPP3CC	ENSP00000315299	ENSP00000240139	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	protein phosphatase 3, catalytic subunit, gamma isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.892
CALML3	PPP3R2	ENSP00000315299	ENSP00000363939	calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates	protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)	0.831
CALML5	PLCB1	ENSP00000369689	ENSP00000338185	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	phospholipase C, beta 1 (phosphoinositide-specific)	0.820
CALML5	PLCB3	ENSP00000369689	ENSP00000279230	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.820
CALML5	PLCG1	ENSP00000369689	ENSP00000244007	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration	0.800
CALML5	PLCG2	ENSP00000369689	ENSP00000352336	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	phospholipase C, gamma 2 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling	0.800
CALML5	PPP3CA	ENSP00000369689	ENSP00000378323	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	0.884
CALML5	PPP3CB	ENSP00000369689	ENSP00000378306	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.884
CALML5	PPP3CC	ENSP00000369689	ENSP00000240139	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	protein phosphatase 3, catalytic subunit, gamma isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.884
CALML5	PPP3R2	ENSP00000369689	ENSP00000363939	calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes	protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)	0.831
CALML6	PLCB1	ENSP00000304643	ENSP00000338185	calmodulin-like 6	phospholipase C, beta 1 (phosphoinositide-specific)	0.832
CALML6	PLCB3	ENSP00000304643	ENSP00000279230	calmodulin-like 6	phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes	0.820
CALML6	PLCG1	ENSP00000304643	ENSP00000244007	calmodulin-like 6	phospholipase C, gamma 1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration	0.810
CALML6	PLCG2	ENSP00000304643	ENSP00000352336	calmodulin-like 6	phospholipase C, gamma 2 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling	0.800

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