node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOB | ENO3 | ENSP00000363988 | ENSP00000324105 | aldolase B, fructose-bisphosphate | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.981 |
ALDOB | FBP2 | ENSP00000363988 | ENSP00000364486 | aldolase B, fructose-bisphosphate | fructose-1,6-bisphosphatase 2 | 0.962 |
ALDOB | GAPDH | ENSP00000363988 | ENSP00000229239 | aldolase B, fructose-bisphosphate | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.982 |
ALDOB | GAPDHS | ENSP00000363988 | ENSP00000222286 | aldolase B, fructose-bisphosphate | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.974 |
ALDOB | GPI | ENSP00000363988 | ENSP00000405573 | aldolase B, fructose-bisphosphate | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.980 |
ALDOB | PFKL | ENSP00000363988 | ENSP00000269848 | aldolase B, fructose-bisphosphate | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOB | PFKM | ENSP00000363988 | ENSP00000345771 | aldolase B, fructose-bisphosphate | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOB | PFKP | ENSP00000363988 | ENSP00000370517 | aldolase B, fructose-bisphosphate | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOB | PKM | ENSP00000363988 | ENSP00000320171 | aldolase B, fructose-bisphosphate | pyruvate kinase, muscle | 0.984 |
ALDOB | TKT | ENSP00000363988 | ENSP00000405455 | aldolase B, fructose-bisphosphate | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.964 |
ENO3 | ALDOB | ENSP00000324105 | ENSP00000363988 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | aldolase B, fructose-bisphosphate | 0.981 |
ENO3 | FBP2 | ENSP00000324105 | ENSP00000364486 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | fructose-1,6-bisphosphatase 2 | 0.490 |
ENO3 | GAPDH | ENSP00000324105 | ENSP00000229239 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.958 |
ENO3 | GAPDHS | ENSP00000324105 | ENSP00000222286 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.942 |
ENO3 | GPI | ENSP00000324105 | ENSP00000405573 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.994 |
ENO3 | PFKL | ENSP00000324105 | ENSP00000269848 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.934 |
ENO3 | PFKM | ENSP00000324105 | ENSP00000345771 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.941 |
ENO3 | PFKP | ENSP00000324105 | ENSP00000370517 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.929 |
ENO3 | PKM | ENSP00000324105 | ENSP00000320171 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | pyruvate kinase, muscle | 0.999 |
ENO3 | TKT | ENSP00000324105 | ENSP00000405455 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate | 0.915 |