Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | HLA-DQA2 | major histocompatibility complex, class II, DQ alpha 2 (255 aa) | ||||||||||||
Predicted Functional Partners:
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 | CD4 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa) |
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0.755 | |||||||||
 | HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 (261 aa) |
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0.674 | |||||||
 | INS | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) (110 aa) |
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0.592 | |||||||||
 | HLA-DPB1 | major histocompatibility complex, class II, DP beta 1 (258 aa) |
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0.544 | |||||||
 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 (266 aa) |
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0.541 | |||||||
 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 (266 aa) |
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0.538 | |||||||
 | GIMAP5 | GTPase, IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity) (307 aa) |
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0.489 | ||||||||||
 | CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa) |
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0.431 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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