node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAED1 | ACER3 | ENSP00000364382 | ENSP00000434480 | AhpC/TSA antioxidant enzyme domain containing 1 | alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity | 0.628 |
AAED1 | ANKRD16 | ENSP00000364382 | ENSP00000369434 | AhpC/TSA antioxidant enzyme domain containing 1 | ankyrin repeat domain 16 | 0.450 |
AAED1 | KIF2A | ENSP00000364382 | ENSP00000385000 | AhpC/TSA antioxidant enzyme domain containing 1 | kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity | 0.630 |
AAED1 | KIF2C | ENSP00000364382 | ENSP00000361298 | AhpC/TSA antioxidant enzyme domain containing 1 | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | 0.456 |
AAED1 | MSRB1 | ENSP00000364382 | ENSP00000355084 | AhpC/TSA antioxidant enzyme domain containing 1 | methionine sulfoxide reductase B1 | 0.599 |
AAED1 | PLEKHA2 | ENSP00000364382 | ENSP00000393860 | AhpC/TSA antioxidant enzyme domain containing 1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | 0.414 |
AAED1 | ZNF366 | ENSP00000364382 | ENSP00000313158 | AhpC/TSA antioxidant enzyme domain containing 1 | zinc finger protein 366; Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases | 0.547 |
AAED1 | ZNF367 | ENSP00000364382 | ENSP00000364405 | AhpC/TSA antioxidant enzyme domain containing 1 | zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes | 0.484 |
ACER3 | AAED1 | ENSP00000434480 | ENSP00000364382 | alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity | AhpC/TSA antioxidant enzyme domain containing 1 | 0.628 |
ACER3 | MSRB1 | ENSP00000434480 | ENSP00000355084 | alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity | methionine sulfoxide reductase B1 | 0.485 |
ANKRD16 | AAED1 | ENSP00000369434 | ENSP00000364382 | ankyrin repeat domain 16 | AhpC/TSA antioxidant enzyme domain containing 1 | 0.450 |
ANKRD16 | PLEKHA2 | ENSP00000369434 | ENSP00000393860 | ankyrin repeat domain 16 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | 0.674 |
KIF2A | AAED1 | ENSP00000385000 | ENSP00000364382 | kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity | AhpC/TSA antioxidant enzyme domain containing 1 | 0.630 |
KIF2A | KIF2C | ENSP00000385000 | ENSP00000361298 | kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | 0.903 |
KIF2C | AAED1 | ENSP00000361298 | ENSP00000364382 | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | AhpC/TSA antioxidant enzyme domain containing 1 | 0.456 |
KIF2C | KIF2A | ENSP00000361298 | ENSP00000385000 | kinesin family member 2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis | kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity | 0.903 |
MSRB1 | AAED1 | ENSP00000355084 | ENSP00000364382 | methionine sulfoxide reductase B1 | AhpC/TSA antioxidant enzyme domain containing 1 | 0.599 |
MSRB1 | ACER3 | ENSP00000355084 | ENSP00000434480 | methionine sulfoxide reductase B1 | alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity | 0.485 |
PLEKHA2 | AAED1 | ENSP00000393860 | ENSP00000364382 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | AhpC/TSA antioxidant enzyme domain containing 1 | 0.414 |
PLEKHA2 | ANKRD16 | ENSP00000393860 | ENSP00000369434 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity) | ankyrin repeat domain 16 | 0.674 |