| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALG11 | METTL8 | ENSP00000430236 | ENSP00000364407 | asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast); Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.563 |
| DCAF17 | METTL8 | ENSP00000364404 | ENSP00000364407 | DDB1 and CUL4 associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.472 |
| GIPC1 | METTL8 | ENSP00000340698 | ENSP00000364407 | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.609 |
| GIPC1 | SOCS1 | ENSP00000340698 | ENSP00000329418 | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.400 |
| GIPC1 | TAX1BP3 | ENSP00000340698 | ENSP00000225525 | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | 0.757 |
| METTL8 | ALG11 | ENSP00000364407 | ENSP00000430236 | methyltransferase like 8; Probable methyltransferase (By similarity) | asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast); Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain | 0.563 |
| METTL8 | DCAF17 | ENSP00000364407 | ENSP00000364404 | methyltransferase like 8; Probable methyltransferase (By similarity) | DDB1 and CUL4 associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.472 |
| METTL8 | GIPC1 | ENSP00000364407 | ENSP00000340698 | methyltransferase like 8; Probable methyltransferase (By similarity) | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | 0.609 |
| METTL8 | NSUN5 | ENSP00000364407 | ENSP00000309126 | methyltransferase like 8; Probable methyltransferase (By similarity) | NOP2/Sun domain family, member 5 | 0.442 |
| METTL8 | SOCS1 | ENSP00000364407 | ENSP00000329418 | methyltransferase like 8; Probable methyltransferase (By similarity) | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | 0.515 |
| METTL8 | TAX1BP3 | ENSP00000364407 | ENSP00000225525 | methyltransferase like 8; Probable methyltransferase (By similarity) | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | 0.860 |
| METTL8 | TRIP12 | ENSP00000364407 | ENSP00000283943 | methyltransferase like 8; Probable methyltransferase (By similarity) | thyroid hormone receptor interactor 12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located [...] | 0.832 |
| METTL8 | TRMT1L | ENSP00000364407 | ENSP00000356476 | methyltransferase like 8; Probable methyltransferase (By similarity) | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.424 |
| NSUN5 | METTL8 | ENSP00000309126 | ENSP00000364407 | NOP2/Sun domain family, member 5 | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.442 |
| NSUN5 | TRMT1L | ENSP00000309126 | ENSP00000356476 | NOP2/Sun domain family, member 5 | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.607 |
| SOCS1 | GIPC1 | ENSP00000329418 | ENSP00000340698 | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | 0.400 |
| SOCS1 | METTL8 | ENSP00000329418 | ENSP00000364407 | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.515 |
| SOCS1 | TAX1BP3 | ENSP00000329418 | ENSP00000225525 | suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of a [...] | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | 0.748 |
| TAX1BP3 | GIPC1 | ENSP00000225525 | ENSP00000340698 | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | GIPC PDZ domain containing family, member 1; May be involved in G protein-linked signaling | 0.757 |
| TAX1BP3 | METTL8 | ENSP00000225525 | ENSP00000364407 | Tax1 (human T-cell leukemia virus type I) binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6 | methyltransferase like 8; Probable methyltransferase (By similarity) | 0.860 |
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