Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RIBC1 | RIB43A domain with coiled-coils 1 (379 aa) | ||||||||||||
Predicted Functional Partners:
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 | C9orf96 | chromosome 9 open reading frame 96 (680 aa) |
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0.588 | ||||||||||
 | CCDC104 | coiled-coil domain containing 104; May act as an effector for ARL3 (342 aa) |
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0.554 | ||||||||||
 | TEKT3 | tektin 3; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity) (490 aa) |
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0.544 | ||||||||||
 | TTC29 | tetratricopeptide repeat domain 29 (475 aa) |
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0.497 | ||||||||||
 | PACRG | PARK2 co-regulated; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (296 aa) |
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0.495 | |||||||||
 | NME5 | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) (212 aa) |
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0.483 | ||||||||||
 | UBASH3B | ubiquitin associated and SH3 domain containing B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination (649 aa) |
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0.474 | ||||||||||
 | TEKT5 | tektin 5; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity) (485 aa) |
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0.470 | ||||||||||
 | DNAI1 | dynein, axonemal, intermediate chain 1; Part of the dynein complex of respiratory cilia (699 aa) |
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0.463 | ||||||||||
 | PACRGL | PARK2 co-regulated-like (221 aa) |
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0.425 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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