node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LCAT | PLA2G15 | ENSP00000264005 | ENSP00000219345 | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | phospholipase A2, group XV; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity | 0.901 |
LCAT | STK19 | ENSP00000264005 | ENSP00000364482 | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | serine/threonine kinase 19 | 0.561 |
PLA2G15 | LCAT | ENSP00000219345 | ENSP00000264005 | phospholipase A2, group XV; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | 0.901 |
PLA2G15 | STK19 | ENSP00000219345 | ENSP00000364482 | phospholipase A2, group XV; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity | serine/threonine kinase 19 | 0.561 |
POLE | STK19 | ENSP00000322570 | ENSP00000364482 | polymerase (DNA directed), epsilon, catalytic subunit; Participates in DNA repair and in chromosomal DNA replication | serine/threonine kinase 19 | 0.615 |
POLR2G | STK19 | ENSP00000301788 | ENSP00000364482 | polymerase (RNA) II (DNA directed) polypeptide G; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex s [...] | serine/threonine kinase 19 | 0.615 |
PRAME | STK19 | ENSP00000381726 | ENSP00000364482 | preferentially expressed antigen in melanoma; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis | serine/threonine kinase 19 | 0.615 |
SF3B4 | STK19 | ENSP00000271628 | ENSP00000364482 | splicing factor 3b, subunit 4, 49kDa | serine/threonine kinase 19 | 0.615 |
SLC29A1 | STK19 | ENSP00000360773 | ENSP00000364482 | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | serine/threonine kinase 19 | 0.615 |
SP3 | STK19 | ENSP00000310301 | ENSP00000364482 | Sp3 transcription factor; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping | serine/threonine kinase 19 | 0.615 |
STK19 | LCAT | ENSP00000364482 | ENSP00000264005 | serine/threonine kinase 19 | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | 0.561 |
STK19 | PLA2G15 | ENSP00000364482 | ENSP00000219345 | serine/threonine kinase 19 | phospholipase A2, group XV; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N- acetylsphingosine and the concomitant release of a lyso- phospholipid (By similarity). May have weak lysophospholipase activity | 0.561 |
STK19 | POLE | ENSP00000364482 | ENSP00000322570 | serine/threonine kinase 19 | polymerase (DNA directed), epsilon, catalytic subunit; Participates in DNA repair and in chromosomal DNA replication | 0.615 |
STK19 | POLR2G | ENSP00000364482 | ENSP00000301788 | serine/threonine kinase 19 | polymerase (RNA) II (DNA directed) polypeptide G; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex s [...] | 0.615 |
STK19 | PRAME | ENSP00000364482 | ENSP00000381726 | serine/threonine kinase 19 | preferentially expressed antigen in melanoma; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis | 0.615 |
STK19 | SF3B4 | ENSP00000364482 | ENSP00000271628 | serine/threonine kinase 19 | splicing factor 3b, subunit 4, 49kDa | 0.615 |
STK19 | SLC29A1 | ENSP00000364482 | ENSP00000360773 | serine/threonine kinase 19 | solute carrier family 29 (nucleoside transporters), member 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs) | 0.615 |
STK19 | SP3 | ENSP00000364482 | ENSP00000310301 | serine/threonine kinase 19 | Sp3 transcription factor; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping | 0.615 |