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SLC30A8 SLC30A8 C2CD4B C2CD4B ADCY5 ADCY5 SUMO4 SUMO4 DGKB DGKB GLIS3 GLIS3 G6PC2 G6PC2 MTNR1B MTNR1B NEUROD1 NEUROD1 ABCB11 ABCB11 NLRP10 NLRP10
"G6PC2" - glucose-6-phosphatase, catalytic, 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
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G6PC2glucose-6-phosphatase, catalytic, 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity) (355 aa)    
Predicted Functional Partners:
MTNR1B
melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (362 aa)
            score_image   0.757
DGKB
diacylglycerol kinase, beta 90kDa (804 aa)
            score_image   0.681
NEUROD1
neuronal differentiation 1 (356 aa)
            score_image   0.659
SLC30A8
solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells (369 aa)
            score_image   0.648
ADCY5
adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)
            score_image   0.607
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes (1321 aa)
            score_image   0.606
C2CD4B
C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion (364 aa)
            score_image   0.580
GLIS3
GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) (930 aa)
            score_image   0.569
SUMO4
SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae); Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires p [...] (95 aa)
            score_image   0.564
NLRP10
NLR family, pyrin domain containing 10; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (655 aa)
            score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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