node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB11 | G6PC2 | ENSP00000263817 | ENSP00000364512 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | glucose-6-phosphatase, catalytic, 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity) | 0.606 |
ABCB11 | MTNR1B | ENSP00000263817 | ENSP00000257068 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.534 |
ADCY5 | C2CD4B | ENSP00000419361 | ENSP00000369755 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | 0.539 |
ADCY5 | DGKB | ENSP00000419361 | ENSP00000382260 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | diacylglycerol kinase, beta 90kDa | 0.711 |
ADCY5 | G6PC2 | ENSP00000419361 | ENSP00000364512 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | glucose-6-phosphatase, catalytic, 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity) | 0.607 |
ADCY5 | GLIS3 | ENSP00000419361 | ENSP00000371398 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) | 0.647 |
ADCY5 | MTNR1B | ENSP00000419361 | ENSP00000257068 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.977 |
ADCY5 | SLC30A8 | ENSP00000419361 | ENSP00000415011 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells | 0.484 |
C2CD4B | ADCY5 | ENSP00000369755 | ENSP00000419361 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.539 |
C2CD4B | DGKB | ENSP00000369755 | ENSP00000382260 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | diacylglycerol kinase, beta 90kDa | 0.585 |
C2CD4B | G6PC2 | ENSP00000369755 | ENSP00000364512 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | glucose-6-phosphatase, catalytic, 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity) | 0.580 |
C2CD4B | GLIS3 | ENSP00000369755 | ENSP00000371398 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) | 0.704 |
C2CD4B | MTNR1B | ENSP00000369755 | ENSP00000257068 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.636 |
C2CD4B | SLC30A8 | ENSP00000369755 | ENSP00000415011 | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells | 0.581 |
DGKB | ADCY5 | ENSP00000382260 | ENSP00000419361 | diacylglycerol kinase, beta 90kDa | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.711 |
DGKB | C2CD4B | ENSP00000382260 | ENSP00000369755 | diacylglycerol kinase, beta 90kDa | C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion | 0.585 |
DGKB | G6PC2 | ENSP00000382260 | ENSP00000364512 | diacylglycerol kinase, beta 90kDa | glucose-6-phosphatase, catalytic, 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity) | 0.681 |
DGKB | GLIS3 | ENSP00000382260 | ENSP00000371398 | diacylglycerol kinase, beta 90kDa | GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) | 0.730 |
DGKB | MTNR1B | ENSP00000382260 | ENSP00000257068 | diacylglycerol kinase, beta 90kDa | melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity | 0.667 |
DGKB | SLC30A8 | ENSP00000382260 | ENSP00000415011 | diacylglycerol kinase, beta 90kDa | solute carrier family 30 (zinc transporter), member 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells | 0.510 |