PADI3 protein (Homo sapiens) - STRING network view

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PADI3

peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins (664 aa)

Predicted Functional Partners:

TCHH

0.664

FLG

0.606

OSGIN1

0.546

KRT31

0.521

SPARC

0.512

MAP1LC3A

0.497

KRT34

0.433

KRT33B

0.433

KRT33A

0.433

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FLG	PADI3	ENSP00000357789	ENSP00000364609	filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.606
KRT31	PADI3	ENSP00000251645	ENSP00000364609	keratin 31	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.521
KRT33A	PADI3	ENSP00000007735	ENSP00000364609	keratin 33A	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.433
KRT33B	PADI3	ENSP00000251646	ENSP00000364609	keratin 33B	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.433
KRT34	PADI3	ENSP00000377570	ENSP00000364609	keratin 34	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.433
MAP1LC3A	PADI3	ENSP00000363970	ENSP00000364609	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.497
OSGIN1	PADI3	ENSP00000355374	ENSP00000364609	oxidative stress induced growth inhibitor 1; Regulates the differentiation and proliferation of normal cells through the regulation of cell death	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.546
PADI3	FLG	ENSP00000364609	ENSP00000357789	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis	0.606
PADI3	KRT31	ENSP00000364609	ENSP00000251645	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	keratin 31	0.521
PADI3	KRT33A	ENSP00000364609	ENSP00000007735	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	keratin 33A	0.433
PADI3	KRT33B	ENSP00000364609	ENSP00000251646	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	keratin 33B	0.433
PADI3	KRT34	ENSP00000364609	ENSP00000377570	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	keratin 34	0.433
PADI3	MAP1LC3A	ENSP00000364609	ENSP00000363970	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes)	0.497
PADI3	OSGIN1	ENSP00000364609	ENSP00000355374	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	oxidative stress induced growth inhibitor 1; Regulates the differentiation and proliferation of normal cells through the regulation of cell death	0.546
PADI3	SPARC	ENSP00000364609	ENSP00000231061	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity	0.512
PADI3	TCHH	ENSP00000364609	ENSP00000357794	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation	0.664
SPARC	PADI3	ENSP00000231061	ENSP00000364609	secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.512
TCHH	PADI3	ENSP00000357794	ENSP00000364609	trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation	peptidyl arginine deiminase, type III; Catalyzes the deimination of arginine residues of proteins	0.664

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