PADI2 protein (Homo sapiens) - STRING network view

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PADI2

peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity) (665 aa)

Predicted Functional Partners:

POFUT2

0.811

FLG

0.533

ADARB1

0.512

SYNGR1

0.503

PAGR1

0.472

MBP

0.459

ZNF347

0.420

IK

0.407

TCHH

0.407

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADARB1	PADI2	ENSP00000353920	ENSP00000364635	adenosine deaminase, RNA-specific, B1	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.512
ADARB1	POFUT2	ENSP00000353920	ENSP00000339613	adenosine deaminase, RNA-specific, B1	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	0.801
FLG	PADI2	ENSP00000357789	ENSP00000364635	filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.533
IK	PADI2	ENSP00000396301	ENSP00000364635	IK cytokine, down-regulator of HLA II; May bind to chromatin	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.407
IK	ZNF347	ENSP00000396301	ENSP00000405218	IK cytokine, down-regulator of HLA II; May bind to chromatin	zinc finger protein 347; May be involved in transcriptional regulation	0.480
MBP	PADI2	ENSP00000372025	ENSP00000364635	myelin basic protein	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.459
PADI2	ADARB1	ENSP00000364635	ENSP00000353920	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	adenosine deaminase, RNA-specific, B1	0.512
PADI2	FLG	ENSP00000364635	ENSP00000357789	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis	0.533
PADI2	IK	ENSP00000364635	ENSP00000396301	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	IK cytokine, down-regulator of HLA II; May bind to chromatin	0.407
PADI2	MBP	ENSP00000364635	ENSP00000372025	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	myelin basic protein	0.459
PADI2	PAGR1	ENSP00000364635	ENSP00000326519	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	PAXIP1 associated glutamate-rich protein 1	0.472
PADI2	POFUT2	ENSP00000364635	ENSP00000339613	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	0.811
PADI2	SYNGR1	ENSP00000364635	ENSP00000332287	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)	0.503
PADI2	TCHH	ENSP00000364635	ENSP00000357794	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation	0.407
PADI2	ZNF347	ENSP00000364635	ENSP00000405218	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	zinc finger protein 347; May be involved in transcriptional regulation	0.420
PAGR1	PADI2	ENSP00000326519	ENSP00000364635	PAXIP1 associated glutamate-rich protein 1	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.472
POFUT2	ADARB1	ENSP00000339613	ENSP00000353920	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	adenosine deaminase, RNA-specific, B1	0.801
POFUT2	PADI2	ENSP00000339613	ENSP00000364635	protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization [...]	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.811
SYNGR1	PADI2	ENSP00000332287	ENSP00000364635	synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.503
TCHH	PADI2	ENSP00000357794	ENSP00000364635	trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation	peptidyl arginine deiminase, type II; Catalyzes the deimination of arginine residues of proteins (By similarity)	0.407

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