CROCC protein (Homo sapiens) - STRING network view

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CROCC

ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis (2017 aa)

Predicted Functional Partners:

NEK2

0.918

CEP68

0.854

RUNX3

0.800

NEK11

0.608

KLC3

0.576

LRRC45

0.504

CENPL

0.485

HAUS6

0.440

TUBGCP3

0.418

BCL9L

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL9L	CROCC	ENSP00000335320	ENSP00000364691	B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.416
CENPL	CROCC	ENSP00000348527	ENSP00000364691	centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.485
CENPL	HAUS6	ENSP00000348527	ENSP00000369871	centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex	HAUS augmin-like complex, subunit 6	0.598
CENPL	TUBGCP3	ENSP00000348527	ENSP00000261965	centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex	tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.487
CEP68	CROCC	ENSP00000367229	ENSP00000364691	centrosomal protein 68kDa	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.854
CROCC	BCL9L	ENSP00000364691	ENSP00000335320	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity)	0.416
CROCC	CENPL	ENSP00000364691	ENSP00000348527	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex	0.485
CROCC	CEP68	ENSP00000364691	ENSP00000367229	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	centrosomal protein 68kDa	0.854
CROCC	HAUS6	ENSP00000364691	ENSP00000369871	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	HAUS augmin-like complex, subunit 6	0.440
CROCC	KLC3	ENSP00000364691	ENSP00000375810	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport	0.576
CROCC	LRRC45	ENSP00000364691	ENSP00000306760	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	leucine rich repeat containing 45	0.504
CROCC	NEK11	ENSP00000364691	ENSP00000372857	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	NIMA-related kinase 11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation	0.608
CROCC	NEK2	ENSP00000364691	ENSP00000355966	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	NIMA-related kinase 2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex [...]	0.918
CROCC	RUNX3	ENSP00000364691	ENSP00000343477	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	runt-related transcription factor 3; CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters	0.800
CROCC	TUBGCP3	ENSP00000364691	ENSP00000261965	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.418
HAUS6	CENPL	ENSP00000369871	ENSP00000348527	HAUS augmin-like complex, subunit 6	centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex	0.598
HAUS6	CROCC	ENSP00000369871	ENSP00000364691	HAUS augmin-like complex, subunit 6	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.440
HAUS6	TUBGCP3	ENSP00000369871	ENSP00000261965	HAUS augmin-like complex, subunit 6	tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome	0.473
KLC3	CROCC	ENSP00000375810	ENSP00000364691	kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.576
LRRC45	CROCC	ENSP00000306760	ENSP00000364691	leucine rich repeat containing 45	ciliary rootlet coiled-coil, rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis	0.504

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