node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLPB | DNAJA2 | ENSP00000294053 | ENSP00000314030 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | 0.777 |
CLPB | DNAJA3 | ENSP00000294053 | ENSP00000262375 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | 0.697 |
CLPB | DNAJB1 | ENSP00000294053 | ENSP00000254322 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | 0.904 |
CLPB | DNAJB11 | ENSP00000294053 | ENSP00000265028 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.704 |
CLPB | GRPEL1 | ENSP00000294053 | ENSP00000264954 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | GrpE-like 1, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins | 0.840 |
CLPB | GRPEL2 | ENSP00000294053 | ENSP00000329558 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) | 0.840 |
CLPB | HSP90AA1 | ENSP00000294053 | ENSP00000335153 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.975 |
CLPB | HSP90AB1 | ENSP00000294053 | ENSP00000325875 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.956 |
CLPB | HSPA1A | ENSP00000294053 | ENSP00000364802 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | heat shock 70kDa protein 1A | 0.957 |
CLPB | STIP1 | ENSP00000294053 | ENSP00000305958 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB) | 0.942 |
DNAJA2 | CLPB | ENSP00000314030 | ENSP00000294053 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.777 |
DNAJA2 | DNAJA3 | ENSP00000314030 | ENSP00000262375 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | 0.420 |
DNAJA2 | DNAJB1 | ENSP00000314030 | ENSP00000254322 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP | 0.796 |
DNAJA2 | GRPEL1 | ENSP00000314030 | ENSP00000264954 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | GrpE-like 1, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins | 0.878 |
DNAJA2 | GRPEL2 | ENSP00000314030 | ENSP00000329558 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | GrpE-like 2, mitochondrial (E. coli); Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity) | 0.872 |
DNAJA2 | HSP90AA1 | ENSP00000314030 | ENSP00000335153 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.991 |
DNAJA2 | HSP90AB1 | ENSP00000314030 | ENSP00000325875 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.985 |
DNAJA2 | HSPA1A | ENSP00000314030 | ENSP00000364802 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | heat shock 70kDa protein 1A | 0.970 |
DNAJA2 | STIP1 | ENSP00000314030 | ENSP00000305958 | DnaJ (Hsp40) homolog, subfamily A, member 2; Co-chaperone of Hsc70 | stress-induced-phosphoprotein 1; Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB) | 0.896 |
DNAJA3 | CLPB | ENSP00000262375 | ENSP00000294053 | DnaJ (Hsp40) homolog, subfamily A, member 3; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma- mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway | ClpB caseinolytic peptidase B homolog (E. coli); May function as a regulatory ATPase and be related to secretion/protein trafficking process | 0.697 |