node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LSM1 | LSM2 | ENSP00000310596 | ENSP00000364813 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.999 |
LSM1 | LSM3 | ENSP00000310596 | ENSP00000302160 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |
LSM1 | LSM5 | ENSP00000310596 | ENSP00000410758 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in U6 snRNP assembly and function. Binds to the 3’ end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro | 0.999 |
LSM1 | LSM6 | ENSP00000310596 | ENSP00000296581 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] | 0.999 |
LSM1 | LSM7 | ENSP00000310596 | ENSP00000252622 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome | 0.999 |
LSM1 | NAA38 | ENSP00000310596 | ENSP00000249299 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | N(alpha)-acetyltransferase 38, NatC auxiliary subunit; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome | 0.958 |
LSM1 | SNRPD1 | ENSP00000310596 | ENSP00000300413 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA | 0.959 |
LSM1 | SNRPD2 | ENSP00000310596 | ENSP00000342374 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity) | 0.992 |
LSM1 | SNRPD3 | ENSP00000310596 | ENSP00000215829 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.982 |
LSM2 | LSM1 | ENSP00000364813 | ENSP00000310596 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |
LSM2 | LSM3 | ENSP00000364813 | ENSP00000302160 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |
LSM2 | LSM5 | ENSP00000364813 | ENSP00000410758 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in U6 snRNP assembly and function. Binds to the 3’ end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro | 0.999 |
LSM2 | LSM6 | ENSP00000364813 | ENSP00000296581 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] | 0.999 |
LSM2 | LSM7 | ENSP00000364813 | ENSP00000252622 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome | 0.999 |
LSM2 | NAA38 | ENSP00000364813 | ENSP00000249299 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | N(alpha)-acetyltransferase 38, NatC auxiliary subunit; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome | 0.999 |
LSM2 | SART3 | ENSP00000364813 | ENSP00000228284 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | 0.987 |
LSM2 | SNRPD1 | ENSP00000364813 | ENSP00000300413 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA | 0.981 |
LSM2 | SNRPD2 | ENSP00000364813 | ENSP00000342374 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity) | 0.996 |
LSM2 | SNRPD3 | ENSP00000364813 | ENSP00000215829 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.986 |
LSM3 | LSM1 | ENSP00000302160 | ENSP00000310596 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.999 |