| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH18A1 | MLH1 | ENSP00000360268 | ENSP00000231790 | aldehyde dehydrogenase 18 family, member A1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.517 |
| ALDH18A1 | MLH3 | ENSP00000360268 | ENSP00000348020 | aldehyde dehydrogenase 18 family, member A1 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | 0.517 |
| ALDH18A1 | MSH4 | ENSP00000360268 | ENSP00000263187 | aldehyde dehydrogenase 18 family, member A1 | mutS homolog 4 (E. coli); Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis | 0.725 |
| ALDH18A1 | MSH5 | ENSP00000360268 | ENSP00000364855 | aldehyde dehydrogenase 18 family, member A1 | mutS homolog 5 (E. coli) | 0.725 |
| ALDH18A1 | PMS1 | ENSP00000360268 | ENSP00000406490 | aldehyde dehydrogenase 18 family, member A1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | 0.517 |
| ALDH18A1 | PMS2 | ENSP00000360268 | ENSP00000265849 | aldehyde dehydrogenase 18 family, member A1 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade [...] | 0.517 |
| ALDH18A1 | RAD51 | ENSP00000360268 | ENSP00000372088 | aldehyde dehydrogenase 18 family, member A1 | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.572 |
| HFM1 | MLH1 | ENSP00000359454 | ENSP00000231790 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.515 |
| HFM1 | MLH3 | ENSP00000359454 | ENSP00000348020 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | 0.653 |
| HFM1 | MSH4 | ENSP00000359454 | ENSP00000263187 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | mutS homolog 4 (E. coli); Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis | 0.765 |
| HFM1 | MSH5 | ENSP00000359454 | ENSP00000364855 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | mutS homolog 5 (E. coli) | 0.776 |
| HFM1 | RAD51 | ENSP00000359454 | ENSP00000372088 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 | 0.562 |
| HFM1 | SPO11 | ENSP00000359454 | ENSP00000360310 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae); Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity) | 0.527 |
| HJURP | MSH5 | ENSP00000414109 | ENSP00000364855 | Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions | mutS homolog 5 (E. coli) | 0.947 |
| MLH1 | ALDH18A1 | ENSP00000231790 | ENSP00000360268 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | aldehyde dehydrogenase 18 family, member A1 | 0.517 |
| MLH1 | HFM1 | ENSP00000231790 | ENSP00000359454 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | 0.515 |
| MLH1 | MLH3 | ENSP00000231790 | ENSP00000348020 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | 0.999 |
| MLH1 | MSH4 | ENSP00000231790 | ENSP00000263187 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | mutS homolog 4 (E. coli); Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis | 0.999 |
| MLH1 | MSH5 | ENSP00000231790 | ENSP00000364855 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | mutS homolog 5 (E. coli) | 0.994 |
| MLH1 | PMS1 | ENSP00000231790 | ENSP00000406490 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | 0.995 |
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