AUH protein (Homo sapiens) - STRING network view

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AUH

AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs (339 aa)

Predicted Functional Partners:

MCCC1

0.944

HMGCL

0.922

HMGCS1

0.916

HMGCS2

0.915

DNAJC19

0.815

HADH

0.791

ACAA2

0.790

ACAT2

0.770

HADHB

0.761

ACAT1

0.760

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAA2	ACAT1	ENSP00000285093	ENSP00000265838	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.972
ACAA2	ACAT2	ENSP00000285093	ENSP00000356015	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	acetyl-CoA acetyltransferase 2	0.908
ACAA2	AUH	ENSP00000285093	ENSP00000364883	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	0.790
ACAA2	HADH	ENSP00000285093	ENSP00000385638	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.987
ACAA2	HMGCL	ENSP00000285093	ENSP00000363614	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.927
ACAA2	HMGCS1	ENSP00000285093	ENSP00000322706	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.983
ACAA2	HMGCS2	ENSP00000285093	ENSP00000358414	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.984
ACAT1	ACAA2	ENSP00000265838	ENSP00000285093	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.972
ACAT1	ACAT2	ENSP00000265838	ENSP00000356015	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	acetyl-CoA acetyltransferase 2	0.841
ACAT1	AUH	ENSP00000265838	ENSP00000364883	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	0.760
ACAT1	HADH	ENSP00000265838	ENSP00000385638	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.984
ACAT1	HADHB	ENSP00000265838	ENSP00000325136	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.929
ACAT1	HMGCL	ENSP00000265838	ENSP00000363614	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.936
ACAT1	HMGCS1	ENSP00000265838	ENSP00000322706	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.992
ACAT1	HMGCS2	ENSP00000265838	ENSP00000358414	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.986
ACAT2	ACAA2	ENSP00000356015	ENSP00000285093	acetyl-CoA acetyltransferase 2	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.908
ACAT2	ACAT1	ENSP00000356015	ENSP00000265838	acetyl-CoA acetyltransferase 2	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.841
ACAT2	AUH	ENSP00000356015	ENSP00000364883	acetyl-CoA acetyltransferase 2	AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	0.770
ACAT2	HADH	ENSP00000356015	ENSP00000385638	acetyl-CoA acetyltransferase 2	hydroxyacyl-CoA dehydrogenase; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA	0.981
ACAT2	HADHB	ENSP00000356015	ENSP00000325136	acetyl-CoA acetyltransferase 2	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.937

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