Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CLIC1 | chloride intracellular channel 1 (241 aa) | ||||||||||||
Predicted Functional Partners:
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 | MAPK15 | mitogen-activated protein kinase 15; In vitro, phosphorylates MBP (544 aa) |
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0.745 | ||||||||||
 | PHC3 | polyhomeotic homolog 3 (Drosophila) (995 aa) |
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0.664 | ||||||||||
 | CLCN4 | chloride channel, voltage-sensitive 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (760 aa) |
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0.584 | ||||||||||
 | B3GALT4 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 (378 aa) |
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0.563 | ||||||||||
 | IL2RG | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins (369 aa) |
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0.516 | ||||||||||
 | HVCN1 | hydrogen voltage-gated channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis (273 aa) |
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0.451 | ||||||||||
 | CLCN3 | chloride channel, voltage-sensitive 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (866 aa) |
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0.446 | ||||||||||
 | ENSG00000179253 | Novel protein (FLJ40547); Uncharacterized protein (140 aa) |
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0.406 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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