MAP3K19 protein (Homo sapiens) - STRING network view

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MAP3K19

mitogen-activated protein kinase kinase kinase 19 (1328 aa)

Predicted Functional Partners:

HSP90AA1

0.916

HSP90AB1

0.916

CDC14B

0.789

DUSP23

0.789

CDC14A

0.789

CDKN3

0.789

PTPDC1

0.789

RASL10A

0.721

DIRAS2

0.709

RSG1

0.709

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC14A	MAP3K19	ENSP00000354916	ENSP00000365005	CDC14 cell division cycle 14 homolog A (S. cerevisiae); Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis	mitogen-activated protein kinase kinase kinase 19	0.789
CDC14B	MAP3K19	ENSP00000364389	ENSP00000365005	CDC14 cell division cycle 14 homolog B (S. cerevisiae); Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases	mitogen-activated protein kinase kinase kinase 19	0.789
CDKN3	MAP3K19	ENSP00000335357	ENSP00000365005	cyclin-dependent kinase inhibitor 3	mitogen-activated protein kinase kinase kinase 19	0.789
DIRAS2	MAP3K19	ENSP00000364919	ENSP00000365005	DIRAS family, GTP-binding RAS-like 2; Displays low GTPase activity and exist predominantly in the GTP-bound form	mitogen-activated protein kinase kinase kinase 19	0.709
DUSP23	MAP3K19	ENSP00000357087	ENSP00000365005	dual specificity phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14)	mitogen-activated protein kinase kinase kinase 19	0.789
HSP90AA1	HSP90AB1	ENSP00000335153	ENSP00000325875	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.999
HSP90AA1	MAP3K19	ENSP00000335153	ENSP00000365005	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	mitogen-activated protein kinase kinase kinase 19	0.916
HSP90AB1	HSP90AA1	ENSP00000325875	ENSP00000335153	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.999
HSP90AB1	MAP3K19	ENSP00000325875	ENSP00000365005	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	mitogen-activated protein kinase kinase kinase 19	0.916
MAP3K19	CDC14A	ENSP00000365005	ENSP00000354916	mitogen-activated protein kinase kinase kinase 19	CDC14 cell division cycle 14 homolog A (S. cerevisiae); Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis	0.789
MAP3K19	CDC14B	ENSP00000365005	ENSP00000364389	mitogen-activated protein kinase kinase kinase 19	CDC14 cell division cycle 14 homolog B (S. cerevisiae); Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases	0.789
MAP3K19	CDKN3	ENSP00000365005	ENSP00000335357	mitogen-activated protein kinase kinase kinase 19	cyclin-dependent kinase inhibitor 3	0.789
MAP3K19	DIRAS2	ENSP00000365005	ENSP00000364919	mitogen-activated protein kinase kinase kinase 19	DIRAS family, GTP-binding RAS-like 2; Displays low GTPase activity and exist predominantly in the GTP-bound form	0.709
MAP3K19	DUSP23	ENSP00000365005	ENSP00000357087	mitogen-activated protein kinase kinase kinase 19	dual specificity phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14)	0.789
MAP3K19	HSP90AA1	ENSP00000365005	ENSP00000335153	mitogen-activated protein kinase kinase kinase 19	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.916
MAP3K19	HSP90AB1	ENSP00000365005	ENSP00000325875	mitogen-activated protein kinase kinase kinase 19	heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function	0.916
MAP3K19	PTPDC1	ENSP00000365005	ENSP00000288976	mitogen-activated protein kinase kinase kinase 19	protein tyrosine phosphatase domain containing 1; May play roles in cilia formation and/or maintenance (By similarity)	0.789
MAP3K19	RASL10A	ENSP00000365005	ENSP00000216101	mitogen-activated protein kinase kinase kinase 19	RAS-like, family 10, member A; Potent inhibitor of cellular proliferation	0.721
MAP3K19	RSG1	ENSP00000365005	ENSP00000364749	mitogen-activated protein kinase kinase kinase 19	REM2 and RAB-like small GTPase 1; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity)	0.709
PTPDC1	MAP3K19	ENSP00000288976	ENSP00000365005	protein tyrosine phosphatase domain containing 1; May play roles in cilia formation and/or maintenance (By similarity)	mitogen-activated protein kinase kinase kinase 19	0.789

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