node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPA1 | CTRC | ENSP00000011292 | ENSP00000365116 | carboxypeptidase A1 (pancreatic) | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.582 |
CTRC | CPA1 | ENSP00000365116 | ENSP00000011292 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | carboxypeptidase A1 (pancreatic) | 0.582 |
CTRC | HTRA1 | ENSP00000365116 | ENSP00000357980 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | 0.628 |
CTRC | PLAUR | ENSP00000365116 | ENSP00000339328 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | plasminogen activator, urokinase receptor | 0.900 |
CTRC | REG1A | ENSP00000365116 | ENSP00000233735 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | 0.822 |
CTRC | RPL14 | ENSP00000365116 | ENSP00000345156 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | ribosomal protein L14 | 0.758 |
CTRC | SERPINA3 | ENSP00000365116 | ENSP00000376793 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.611 |
CTRC | SPINK1 | ENSP00000365116 | ENSP00000296695 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas | 0.872 |
CTRC | ST13 | ENSP00000365116 | ENSP00000216218 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | 0.602 |
CTRC | STATH | ENSP00000365116 | ENSP00000246895 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface | 0.608 |
CTRC | UBC | ENSP00000365116 | ENSP00000344818 | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | ubiquitin C | 0.585 |
HTRA1 | CTRC | ENSP00000357980 | ENSP00000365116 | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.628 |
HTRA1 | REG1A | ENSP00000357980 | ENSP00000233735 | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | 0.453 |
HTRA1 | RPL14 | ENSP00000357980 | ENSP00000345156 | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | ribosomal protein L14 | 0.606 |
HTRA1 | SPINK1 | ENSP00000357980 | ENSP00000296695 | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas | 0.459 |
PLAUR | CTRC | ENSP00000339328 | ENSP00000365116 | plasminogen activator, urokinase receptor | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.900 |
REG1A | CTRC | ENSP00000233735 | ENSP00000365116 | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity | 0.822 |
REG1A | HTRA1 | ENSP00000233735 | ENSP00000357980 | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | 0.453 |
REG1A | RPL14 | ENSP00000233735 | ENSP00000345156 | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | ribosomal protein L14 | 0.742 |
REG1A | SPINK1 | ENSP00000233735 | ENSP00000296695 | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas | 0.749 |